Recombinant Gelatin Microspheres: Novel Formulations for Tissue Repair?

Annemarie Tuin; Sebastiaan G. Kluijtmans; Jan B. Bouwstra; Martin C. Harmsen; Marja J. A. Van Luyn

doi:10.1089/ten.tea.2009.0592

Recombinant Gelatin Microspheres: Novel Formulations for Tissue Repair?

Annemarie Tuin^*, Sebastiaan G. Kluijtmans, Jan B. Bouwstra, Martin C. Harmsen, Marja J. A. Van Luyn

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Microspheres (MSs) can function as multifunctional scaffolds in different approaches of tissue repair (TR), as a filler, a slow-release depot for growth factors, or a delivery vehicle for cells. Natural cell adhesion-supporting extracellular matrix components like gelatin are good materials for these purposes. Recombinant production of gelatin allows for on-demand design of gelatins, which is why we aim at developing recombinant gelatin (RG) MSs for TR. Two types of MSs (50

Original language	English
Pages (from-to)	1811-1821
Number of pages	11
Journal	Tissue Engineering. Part A
Volume	16
Issue number	6
DOIs	https://doi.org/10.1089/ten.tea.2009.0592
Publication status	Published - Jun-2010

Keywords

FOREIGN-BODY REACTION
IN-VIVO
MATRIX METALLOPROTEINASES
GENE-EXPRESSION
STEM-CELLS
DELIVERY
SCAFFOLDS
TRANSPLANTATION
KERATINOCYTES
BIOMATERIALS

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10.1089/ten.tea.2009.0592

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Cite this

@article{4944add3397442598fd21d63fc048b03,

title = "Recombinant Gelatin Microspheres: Novel Formulations for Tissue Repair?",

abstract = "Microspheres (MSs) can function as multifunctional scaffolds in different approaches of tissue repair (TR), as a filler, a slow-release depot for growth factors, or a delivery vehicle for cells. Natural cell adhesion-supporting extracellular matrix components like gelatin are good materials for these purposes. Recombinant production of gelatin allows for on-demand design of gelatins, which is why we aim at developing recombinant gelatin (RG) MSs for TR. Two types of MSs (50",

keywords = "FOREIGN-BODY REACTION, IN-VIVO, MATRIX METALLOPROTEINASES, GENE-EXPRESSION, STEM-CELLS, DELIVERY, SCAFFOLDS, TRANSPLANTATION, KERATINOCYTES, BIOMATERIALS",

author = "Annemarie Tuin and Kluijtmans, {Sebastiaan G.} and Bouwstra, {Jan B.} and Harmsen, {Martin C.} and {Van Luyn}, {Marja J. A.}",

year = "2010",

month = jun,

doi = "10.1089/ten.tea.2009.0592",

language = "English",

volume = "16",

pages = "1811--1821",

journal = "Tissue Engineering. Part A",

issn = "1937-3341",

publisher = "MARY ANN LIEBERT, INC",

number = "6",

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TY - JOUR

T1 - Recombinant Gelatin Microspheres

T2 - Novel Formulations for Tissue Repair?

AU - Tuin, Annemarie

AU - Kluijtmans, Sebastiaan G.

AU - Bouwstra, Jan B.

AU - Harmsen, Martin C.

AU - Van Luyn, Marja J. A.

PY - 2010/6

Y1 - 2010/6

N2 - Microspheres (MSs) can function as multifunctional scaffolds in different approaches of tissue repair (TR), as a filler, a slow-release depot for growth factors, or a delivery vehicle for cells. Natural cell adhesion-supporting extracellular matrix components like gelatin are good materials for these purposes. Recombinant production of gelatin allows for on-demand design of gelatins, which is why we aim at developing recombinant gelatin (RG) MSs for TR. Two types of MSs (50

AB - Microspheres (MSs) can function as multifunctional scaffolds in different approaches of tissue repair (TR), as a filler, a slow-release depot for growth factors, or a delivery vehicle for cells. Natural cell adhesion-supporting extracellular matrix components like gelatin are good materials for these purposes. Recombinant production of gelatin allows for on-demand design of gelatins, which is why we aim at developing recombinant gelatin (RG) MSs for TR. Two types of MSs (50

KW - FOREIGN-BODY REACTION

KW - IN-VIVO

KW - MATRIX METALLOPROTEINASES

KW - GENE-EXPRESSION

KW - STEM-CELLS

KW - DELIVERY

KW - SCAFFOLDS

KW - TRANSPLANTATION

KW - KERATINOCYTES

KW - BIOMATERIALS

U2 - 10.1089/ten.tea.2009.0592

DO - 10.1089/ten.tea.2009.0592

M3 - Article

SN - 1937-3341

VL - 16

SP - 1811

EP - 1821

JO - Tissue Engineering. Part A

JF - Tissue Engineering. Part A

IS - 6

ER -