Recombinant human interleukin-6 induces hepatocyte growth factor production in cancer patients

K. P. Jong, de; M.M. Van Gameren; J. Bijzet; P.C. Limburg; W.J. Sluiter; M.J.H. Slooff; E.G.E. De Vries

doi:10.1080/00365520119333

Recombinant human interleukin-6 induces hepatocyte growth factor production in cancer patients

K. P. Jong, de, M.M. Van Gameren, J. Bijzet, P.C. Limburg, W.J. Sluiter, M.J.H. Slooff, E.G.E. De Vries

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Experiments in animals demonstrate an important role for interleukin-6 (IL-6) in liver regeneration. It is suggested that IL-6 initiates hepatocyte growth factor (HGF) synthesis. Methods: The aim of the study was to examine the effect of exogenously administered recombinant human IL-6 (rhlL-6), in doses of 0.5. 1.0, 2.5, 5, 10 and 20 mug/kg/day, on HGF serum levels in humans. Serum HGF levels were measured on days 1, 2, 3, 8 and 15 and were correlated with serum amyloid A (SAA) and C-reactive protein (CRP). Results: Median HGF levels increased to 124% at day 3 (P <0.05) and 157% (P <0.05) at day 8 as compared to 100% levels at day 1. An IL-6 dose-dependent increase in HGF was found at day 8 (R=0.53, P <0.02). The percentual change in serum HGF level at day 8 correlated with IL-6 serum levels at day (R = 0.59, P <0.01). HGF levels did not correlate with CRP and SAA. Conclusion: In humans, rhIL-6 administration resulted in an increase in serum HGF levels.

Original language	English
Pages (from-to)	636-640
Number of pages	5
Journal	SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
Volume	36
Issue number	6
DOIs	https://doi.org/10.1080/00365520119333
Publication status	Published - 24-Dec-2001

Keywords

acute phase proteins
hepatocyte growth factor
interleukin-6
liver regeneration
LIVER-REGENERATION
SCATTER FACTOR
BREAST-CANCER
CELL-LINES
SERUM
HGF
METASTASIS
INDUCTION
DISEASES
TISSUES

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@article{df5942f7dbfd4237be36d524518efa7a,

title = "Recombinant human interleukin-6 induces hepatocyte growth factor production in cancer patients",

abstract = "Background: Experiments in animals demonstrate an important role for interleukin-6 (IL-6) in liver regeneration. It is suggested that IL-6 initiates hepatocyte growth factor (HGF) synthesis. Methods: The aim of the study was to examine the effect of exogenously administered recombinant human IL-6 (rhlL-6), in doses of 0.5. 1.0, 2.5, 5, 10 and 20 mug/kg/day, on HGF serum levels in humans. Serum HGF levels were measured on days 1, 2, 3, 8 and 15 and were correlated with serum amyloid A (SAA) and C-reactive protein (CRP). Results: Median HGF levels increased to 124% at day 3 (P <0.05) and 157% (P <0.05) at day 8 as compared to 100% levels at day 1. An IL-6 dose-dependent increase in HGF was found at day 8 (R=0.53, P <0.02). The percentual change in serum HGF level at day 8 correlated with IL-6 serum levels at day (R = 0.59, P <0.01). HGF levels did not correlate with CRP and SAA. Conclusion: In humans, rhIL-6 administration resulted in an increase in serum HGF levels.",

keywords = "acute phase proteins, hepatocyte growth factor, interleukin-6, liver regeneration, LIVER-REGENERATION, SCATTER FACTOR, BREAST-CANCER, CELL-LINES, SERUM, HGF, METASTASIS, INDUCTION, DISEASES, TISSUES",

author = "{Jong, de}, {K. P.} and {Van Gameren}, M.M. and J. Bijzet and P.C. Limburg and W.J. Sluiter and M.J.H. Slooff and {De Vries}, E.G.E.",

year = "2001",

month = dec,

day = "24",

doi = "10.1080/00365520119333",

language = "English",

volume = "36",

pages = "636--640",

journal = "SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY",

issn = "0036-5521",

publisher = "Taylor & Francis Group",

number = "6",

}

TY - JOUR

T1 - Recombinant human interleukin-6 induces hepatocyte growth factor production in cancer patients

AU - Jong, de, K. P.

AU - Van Gameren, M.M.

AU - Bijzet, J.

AU - Limburg, P.C.

AU - Sluiter, W.J.

AU - Slooff, M.J.H.

AU - De Vries, E.G.E.

PY - 2001/12/24

Y1 - 2001/12/24

N2 - Background: Experiments in animals demonstrate an important role for interleukin-6 (IL-6) in liver regeneration. It is suggested that IL-6 initiates hepatocyte growth factor (HGF) synthesis. Methods: The aim of the study was to examine the effect of exogenously administered recombinant human IL-6 (rhlL-6), in doses of 0.5. 1.0, 2.5, 5, 10 and 20 mug/kg/day, on HGF serum levels in humans. Serum HGF levels were measured on days 1, 2, 3, 8 and 15 and were correlated with serum amyloid A (SAA) and C-reactive protein (CRP). Results: Median HGF levels increased to 124% at day 3 (P <0.05) and 157% (P <0.05) at day 8 as compared to 100% levels at day 1. An IL-6 dose-dependent increase in HGF was found at day 8 (R=0.53, P <0.02). The percentual change in serum HGF level at day 8 correlated with IL-6 serum levels at day (R = 0.59, P <0.01). HGF levels did not correlate with CRP and SAA. Conclusion: In humans, rhIL-6 administration resulted in an increase in serum HGF levels.

AB - Background: Experiments in animals demonstrate an important role for interleukin-6 (IL-6) in liver regeneration. It is suggested that IL-6 initiates hepatocyte growth factor (HGF) synthesis. Methods: The aim of the study was to examine the effect of exogenously administered recombinant human IL-6 (rhlL-6), in doses of 0.5. 1.0, 2.5, 5, 10 and 20 mug/kg/day, on HGF serum levels in humans. Serum HGF levels were measured on days 1, 2, 3, 8 and 15 and were correlated with serum amyloid A (SAA) and C-reactive protein (CRP). Results: Median HGF levels increased to 124% at day 3 (P <0.05) and 157% (P <0.05) at day 8 as compared to 100% levels at day 1. An IL-6 dose-dependent increase in HGF was found at day 8 (R=0.53, P <0.02). The percentual change in serum HGF level at day 8 correlated with IL-6 serum levels at day (R = 0.59, P <0.01). HGF levels did not correlate with CRP and SAA. Conclusion: In humans, rhIL-6 administration resulted in an increase in serum HGF levels.

KW - acute phase proteins

KW - hepatocyte growth factor

KW - interleukin-6

KW - liver regeneration

KW - LIVER-REGENERATION

KW - SCATTER FACTOR

KW - BREAST-CANCER

KW - CELL-LINES

KW - SERUM

KW - HGF

KW - METASTASIS

KW - INDUCTION

KW - DISEASES

KW - TISSUES

U2 - 10.1080/00365520119333

DO - 10.1080/00365520119333

M3 - Article

SN - 0036-5521

VL - 36

SP - 636

EP - 640

JO - SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

JF - SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

IS - 6

ER -

Recombinant human interleukin-6 induces hepatocyte growth factor production in cancer patients

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