Recovering object-location memories after sleep deprivation-induced amnesia

Youri G Bolsius, Pim R A Heckman, Camilla Paraciani, Sophia Wilhelm, Frank Raven, Elroy L Meijer, Martien J H Kas, Steve Ramirez, Peter Meerlo, Robbert Havekes*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
50 Downloads (Pure)

Abstract

It is well established that sleep deprivation after learning impairs hippocampal memory processes and can cause amnesia. It is unknown, however, whether sleep deprivation leads to the loss of information or merely the suboptimal storage of information that is difficult to retrieve. Here, we show that hippocampal object-location memories formed under sleep deprivation conditions can be successfully retrieved multiple days following training, using optogenetic dentate gyrus (DG) memory engram activation or treatment with the clinically approved phosphodiesterase 4 (PDE4) inhibitor roflumilast. Moreover, the combination of optogenetic DG memory engram activation and roflumilast treatment, 2 days following training and sleep deprivation, made the memory more persistently accessible for retrieval even several days later (i.e., without further optogenetic or pharmacological manipulation). Altogether, our studies in mice demonstrate that sleep deprivation does not necessarily cause memory loss but instead leads to the suboptimal storage of information that cannot be retrieved without drug treatment or optogenetic stimulation. Furthermore, our findings suggest that object-location memories, consolidated under sleep deprivation conditions and thought to be lost, can be made accessible again several days after the learning and sleep deprivation episode, using the clinically approved PDE4 inhibitor roflumilast.

Original languageEnglish
Pages (from-to)298-308.e5
Number of pages18
JournalCurrent Biology
Volume33
Early online date22-Dec-2022
DOIs
Publication statusPublished - Jan-2023

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