Rectal versus oral absorption of codeine phosphate in man

F Moolenaar*, G Grasmeijer, J Visser, DKF Meijer

*Corresponding author for this work

    Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

    21 Citations (Scopus)

    Abstract

    Rectal absorption of codeine phosphate from various dosage forms was studied in man. The rectal dosage forms included aqueous solutions and fatty suppositories. A comparison was made with an orally administered solution. The plasma concentrations of codeine were measured by means of HPLC analysis after a single dose of 60 mg codeine phosphate in a cross-over study in 7 volunteers. Compared with oral dosing rectal absorption from an aqueous solution or a fatty suppository produced an almost identical plasma concentration profile with similar interindividual variations. Comparing the absorption rate characteristics it appeared that rectal absorption from an alkaline solution containing codeine phosphate proceeded significantly (P less than 0.05) more rapid than after oral dosing. No essential difference in bioavailability was observed between the various rectal and oral dosage forms.
    Original languageEnglish
    Pages (from-to)195-199
    Number of pages5
    JournalBiopharmaceutics & drug disposition
    Volume4
    Issue number2
    DOIs
    Publication statusPublished - 1983

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