Recurrent Respiratory Papillomatosis

Frederik G. Dikkers*, Riaz Y. Seedat, Michel R.M.San Giorgi

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

    1 Citation (Scopus)
    159 Downloads (Pure)

    Abstract

    Recurrent respiratory papillomatosis (RRP) is a condition caused by human papillomavirus (HPV) that occurs in both children and adults, characterized by recurrent growths of intraluminal papillomas in the airway, usually in the larynx. Patients present with dysphonia (both roughness and breathiness), coughing, and eventually airway obstruction. The most common causative HPV types are HPV6 and HPV11. RRP has a significant adverse effect on quality of life. In the absence of a curative treatment, patients have to undergo frequent surgical procedures. Some patients require more than a 100 procedures. Several adjuvant therapies have been proposed to reduce the severity of disease and the number of surgical interventions. The introduction of vaccines against HPV6 and HPV11 can reduce the incidence of RRP.

    Original languageEnglish
    Title of host publicationTextbook of Surgery of Larynx and Trachea
    PublisherSpringer International Publishing AG
    Chapter14
    Pages199-211
    Number of pages13
    ISBN (Electronic)9783031096211
    ISBN (Print)9783031096204
    DOIs
    Publication statusPublished - 2022

    Keywords

    • HPV
    • Laryngeal papillomatosis
    • Larynx
    • Papilloma
    • Recurrent respiratory papillomatosis

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