Red Blood Cell Transfusions Affect Intestinal and Cerebral Oxygenation Differently in Preterm Infants with and without Subsequent Necrotizing Enterocolitis

Willemien S. Kalteren; Sara J. Kuik; Koenraad N. J. A. Van Braeckel; Jan B. F. Hulscher; Arend F. Bos; Elisabeth M. W. Kooi; Michelle E. van der Laan

doi:10.1055/s-0038-1636532

Red Blood Cell Transfusions Affect Intestinal and Cerebral Oxygenation Differently in Preterm Infants with and without Subsequent Necrotizing Enterocolitis

Willemien S. Kalteren^*, Sara J. Kuik, Koenraad N. J. A. Van Braeckel, Jan B. F. Hulscher, Arend F. Bos, Elisabeth M. W. Kooi, Michelle E. van der Laan

^*Corresponding author for this work

Reproductive Origins of Adult Health and Disease (ROAHD)

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objective To assess intestinal and cerebral oxygenation during and after red blood cell (RBC) transfusions in preterms with or without subsequent transfusion-associated necrotizing enterocolitis (TANEC).

Study Design In preterms of

Results In TANEC infants, r (c) SO (2) was lower during and after RBC transfusions than in controls, median (interquartile range) 55% (50-62) versus 72% (65-75), p

Conclusion In preterm infants lower r (c) SO (2) , but not r (int) SO (2) , values during and after RBC transfusions are associated with TANEC. Lower r (int) SO (2) and r (c) SO (2) variabilities after RBC transfusions may represent a diminished capacity for vascular adaptation, possibly leading to TANEC.

Original language	English
Pages (from-to)	1031-1037
Number of pages	7
Journal	American Journal of Perinatology
Volume	35
Issue number	11
DOIs	https://doi.org/10.1055/s-0038-1636532
Publication status	Published - Sept-2018

Keywords

red blood cell transfusion
intestinal regional tissue oxygen saturation
cerebral regional tissue oxygen saturation
necrotizing enterocolitis
preterm infants
variability
hemoglobin
near-infrared spectroscopy
NEAR-INFRARED SPECTROSCOPY
BIRTH-WEIGHT INFANTS
SPLANCHNIC TISSUE OXYGENATION
CLINICAL SEPSIS
ASSOCIATION
ANEMIA
RISK
VARIABILITY

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Red Blood Cell Transfusions Affect Intestinal and Cerebral Oxygenation Differently in Preterm Infants with and without Subsequent Necrotizing EnterocolitisFinal publisher's version, 246 KBLicence: Taverne

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Kalteren, W. S., Kuik, S. J., Van Braeckel, K. N. J. A., Hulscher, J. B. F., Bos, A. F., Kooi, E. M. W., & van der Laan, M. E. (2018). Red Blood Cell Transfusions Affect Intestinal and Cerebral Oxygenation Differently in Preterm Infants with and without Subsequent Necrotizing Enterocolitis. American Journal of Perinatology, 35(11), 1031-1037. https://doi.org/10.1055/s-0038-1636532

@article{bd201e293a8c469d83b2cca25081411e,

title = "Red Blood Cell Transfusions Affect Intestinal and Cerebral Oxygenation Differently in Preterm Infants with and without Subsequent Necrotizing Enterocolitis",

abstract = "Objective To assess intestinal and cerebral oxygenation during and after red blood cell (RBC) transfusions in preterms with or without subsequent transfusion-associated necrotizing enterocolitis (TANEC).Study Design In preterms ofResults In TANEC infants, r (c) SO (2) was lower during and after RBC transfusions than in controls, median (interquartile range) 55% (50-62) versus 72% (65-75), pConclusion In preterm infants lower r (c) SO (2) , but not r (int) SO (2) , values during and after RBC transfusions are associated with TANEC. Lower r (int) SO (2) and r (c) SO (2) variabilities after RBC transfusions may represent a diminished capacity for vascular adaptation, possibly leading to TANEC.",

keywords = "red blood cell transfusion, intestinal regional tissue oxygen saturation, cerebral regional tissue oxygen saturation, necrotizing enterocolitis, preterm infants, variability, hemoglobin, near-infrared spectroscopy, NEAR-INFRARED SPECTROSCOPY, BIRTH-WEIGHT INFANTS, SPLANCHNIC TISSUE OXYGENATION, CLINICAL SEPSIS, ASSOCIATION, ANEMIA, RISK, VARIABILITY",

author = "Kalteren, {Willemien S.} and Kuik, {Sara J.} and {Van Braeckel}, {Koenraad N. J. A.} and Hulscher, {Jan B. F.} and Bos, {Arend F.} and Kooi, {Elisabeth M. W.} and {van der Laan}, {Michelle E.}",

year = "2018",

month = sep,

doi = "10.1055/s-0038-1636532",

language = "English",

volume = "35",

pages = "1031--1037",

journal = "American Journal of Perinatology",

issn = "0735-1631",

publisher = "THIEME MEDICAL PUBL INC",

number = "11",

}

Red Blood Cell Transfusions Affect Intestinal and Cerebral Oxygenation Differently in Preterm Infants with and without Subsequent Necrotizing Enterocolitis. / Kalteren, Willemien S.; Kuik, Sara J.; Van Braeckel, Koenraad N. J. A. et al.
In: American Journal of Perinatology, Vol. 35, No. 11, 09.2018, p. 1031-1037.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Red Blood Cell Transfusions Affect Intestinal and Cerebral Oxygenation Differently in Preterm Infants with and without Subsequent Necrotizing Enterocolitis

AU - Kalteren, Willemien S.

AU - Kuik, Sara J.

AU - Van Braeckel, Koenraad N. J. A.

AU - Hulscher, Jan B. F.

AU - Bos, Arend F.

AU - Kooi, Elisabeth M. W.

AU - van der Laan, Michelle E.

PY - 2018/9

Y1 - 2018/9

N2 - Objective To assess intestinal and cerebral oxygenation during and after red blood cell (RBC) transfusions in preterms with or without subsequent transfusion-associated necrotizing enterocolitis (TANEC).Study Design In preterms ofResults In TANEC infants, r (c) SO (2) was lower during and after RBC transfusions than in controls, median (interquartile range) 55% (50-62) versus 72% (65-75), pConclusion In preterm infants lower r (c) SO (2) , but not r (int) SO (2) , values during and after RBC transfusions are associated with TANEC. Lower r (int) SO (2) and r (c) SO (2) variabilities after RBC transfusions may represent a diminished capacity for vascular adaptation, possibly leading to TANEC.

AB - Objective To assess intestinal and cerebral oxygenation during and after red blood cell (RBC) transfusions in preterms with or without subsequent transfusion-associated necrotizing enterocolitis (TANEC).Study Design In preterms ofResults In TANEC infants, r (c) SO (2) was lower during and after RBC transfusions than in controls, median (interquartile range) 55% (50-62) versus 72% (65-75), pConclusion In preterm infants lower r (c) SO (2) , but not r (int) SO (2) , values during and after RBC transfusions are associated with TANEC. Lower r (int) SO (2) and r (c) SO (2) variabilities after RBC transfusions may represent a diminished capacity for vascular adaptation, possibly leading to TANEC.

KW - red blood cell transfusion

KW - intestinal regional tissue oxygen saturation

KW - cerebral regional tissue oxygen saturation

KW - necrotizing enterocolitis

KW - preterm infants

KW - variability

KW - hemoglobin

KW - near-infrared spectroscopy

KW - NEAR-INFRARED SPECTROSCOPY

KW - BIRTH-WEIGHT INFANTS

KW - SPLANCHNIC TISSUE OXYGENATION

KW - CLINICAL SEPSIS

KW - ASSOCIATION

KW - ANEMIA

KW - RISK

KW - VARIABILITY

U2 - 10.1055/s-0038-1636532

DO - 10.1055/s-0038-1636532

M3 - Article

SN - 0735-1631

VL - 35

SP - 1031

EP - 1037

JO - American Journal of Perinatology

JF - American Journal of Perinatology

IS - 11

ER -

Red Blood Cell Transfusions Affect Intestinal and Cerebral Oxygenation Differently in Preterm Infants with and without Subsequent Necrotizing Enterocolitis

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Keywords

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