Reducing dietary intake of linoleic acid of mouse dams during lactation increases offspring brain n-3 LCPUFA content

L. Schipper*, A. Oosting, A. J. W. Scheurink, G. van Dijk, E. M. van der Beek

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

Omega (n-)3 and n-6 long chain polyunsaturated fatty acids (LCPUFA) accumulation in the infant brain after birth is strongly driven by dietary supply of n-3 and n-6 LCPUFAs and their C18 precursors through breast milk or infant formula. n-3 LCPUFA accretion is associated with positive effects on neurodevelopmental outcome whereas high n-6 LCPUFA accumulation is considered disadvantageous. Maternal diet is crucial for breast milk fatty acid composition. Unfortunately, global increases in linoleic acid (C18:2n-6; LA) intake have dramatically increased n-6 LCPUFA and reduced n-3 LCPUFA availability for breastfed infants. We investigated the effects of reducing maternal dietary LA, or increasing n-3 LCPUFA, during lactation on milk and offspring brain fatty acids in mice. Offspring brain n-3 LCPUFA was higher following both interventions, although effects were mediated by different mechanisms. Because of competitive interactions between n-3 and n-6 fatty acids, lowering maternal LA intake may support neurodevelopment in breastfed infants. (C) 2016 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)8-15
Number of pages8
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume110
DOIs
Publication statusPublished - Jul-2016

Keywords

  • Linoleic acid
  • n-3 Long chain polyunsaturated fatty acids
  • Maternal diet
  • Milk
  • Brain development
  • POLYUNSATURATED FATTY-ACIDS
  • DOCOSAHEXAENOIC ACID
  • HUMAN-MILK
  • BREAST-MILK
  • DEVELOPING RAT
  • MATERNAL DIET
  • FED INFANTS
  • YOUNG-RATS
  • OLEIC-ACID
  • CHAIN

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