Regeneration and activation of liver progenitor cells in liver cirrhosis

Yanze Yin; Defu Kong; Kang He; Qiang Xia

doi:10.1016/j.gendis.2020.07.016

Regeneration and activation of liver progenitor cells in liver cirrhosis

Yanze Yin, Defu Kong, Kang He^*, Qiang Xia^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

59 Downloads (Pure)

Abstract

Cirrhosis is characterized as the progress of regenerative nodules surrounded by fibrous bands in response to chronic hepatic injury and causes portal hypertension and end stage hepatic disease. Following liver injury, liver progenitor cells (LPCs) can be activated and differentiate into hepatocytes in order to awaken liver regeneration and reach homeostasis. Recent research has uncovered some new sources of LPCs. Here, we update the mechanisms of LPCs-mediated liver regeneration in cirrhosis by introducing the origin of LPCs and LPCs' niche with a discussion of the influence of LPC-related cells. This article analyzes the mechanism of regeneration and activation of LPCs in cirrhosis in recent years aiming to provide help for clinical application. Copyright (C) 2020, Chongqing Medical University. Production and hosting by Elsevier B.V.

Original language	English
Pages (from-to)	623-628
Number of pages	6
Journal	Genes & diseases
Volume	8
Issue number	5
DOIs	https://doi.org/10.1016/j.gendis.2020.07.016
Publication status	Published - Sept-2021

Keywords

Activation
Cytokines
Extracellular matrix
Hepatic stellate cells
Liver cirrhosis
Liver progenitor cells
Liver regeneration
Niche
HEPATIC STELLATE CELLS
ADULT LIVER
STEM-CELLS
HEPATOCYTES
DIFFERENTIATION
CHOLANGIOCYTES
FIBROSIS
GROWTH
EXPRESSION
SIGNALS

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10.1016/j.gendis.2020.07.016Licence: CC BY-NC-ND

Regeneration and activation of liverprogenitor cells in liver cirrhosisFinal publisher's version, 535 KBLicence: CC BY-NC-ND

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Cite this

@article{2f02986d4c9f4bfca4211818fe3427c2,

title = "Regeneration and activation of liver progenitor cells in liver cirrhosis",

abstract = "Cirrhosis is characterized as the progress of regenerative nodules surrounded by fibrous bands in response to chronic hepatic injury and causes portal hypertension and end stage hepatic disease. Following liver injury, liver progenitor cells (LPCs) can be activated and differentiate into hepatocytes in order to awaken liver regeneration and reach homeostasis. Recent research has uncovered some new sources of LPCs. Here, we update the mechanisms of LPCs-mediated liver regeneration in cirrhosis by introducing the origin of LPCs and LPCs' niche with a discussion of the influence of LPC-related cells. This article analyzes the mechanism of regeneration and activation of LPCs in cirrhosis in recent years aiming to provide help for clinical application. Copyright (C) 2020, Chongqing Medical University. Production and hosting by Elsevier B.V.",

keywords = "Activation, Cytokines, Extracellular matrix, Hepatic stellate cells, Liver cirrhosis, Liver progenitor cells, Liver regeneration, Niche, HEPATIC STELLATE CELLS, ADULT LIVER, STEM-CELLS, HEPATOCYTES, DIFFERENTIATION, CHOLANGIOCYTES, FIBROSIS, GROWTH, EXPRESSION, SIGNALS",

author = "Yanze Yin and Defu Kong and Kang He and Qiang Xia",

year = "2021",

month = sep,

doi = "10.1016/j.gendis.2020.07.016",

language = "English",

volume = "8",

pages = "623--628",

journal = "Genes & diseases",

issn = "2352-4820",

publisher = "Elsevier",

number = "5",

}

TY - JOUR

T1 - Regeneration and activation of liver progenitor cells in liver cirrhosis

AU - Yin, Yanze

AU - Kong, Defu

AU - He, Kang

AU - Xia, Qiang

PY - 2021/9

Y1 - 2021/9

N2 - Cirrhosis is characterized as the progress of regenerative nodules surrounded by fibrous bands in response to chronic hepatic injury and causes portal hypertension and end stage hepatic disease. Following liver injury, liver progenitor cells (LPCs) can be activated and differentiate into hepatocytes in order to awaken liver regeneration and reach homeostasis. Recent research has uncovered some new sources of LPCs. Here, we update the mechanisms of LPCs-mediated liver regeneration in cirrhosis by introducing the origin of LPCs and LPCs' niche with a discussion of the influence of LPC-related cells. This article analyzes the mechanism of regeneration and activation of LPCs in cirrhosis in recent years aiming to provide help for clinical application. Copyright (C) 2020, Chongqing Medical University. Production and hosting by Elsevier B.V.

AB - Cirrhosis is characterized as the progress of regenerative nodules surrounded by fibrous bands in response to chronic hepatic injury and causes portal hypertension and end stage hepatic disease. Following liver injury, liver progenitor cells (LPCs) can be activated and differentiate into hepatocytes in order to awaken liver regeneration and reach homeostasis. Recent research has uncovered some new sources of LPCs. Here, we update the mechanisms of LPCs-mediated liver regeneration in cirrhosis by introducing the origin of LPCs and LPCs' niche with a discussion of the influence of LPC-related cells. This article analyzes the mechanism of regeneration and activation of LPCs in cirrhosis in recent years aiming to provide help for clinical application. Copyright (C) 2020, Chongqing Medical University. Production and hosting by Elsevier B.V.

KW - Activation

KW - Cytokines

KW - Extracellular matrix

KW - Hepatic stellate cells

KW - Liver cirrhosis

KW - Liver progenitor cells

KW - Liver regeneration

KW - Niche

KW - HEPATIC STELLATE CELLS

KW - ADULT LIVER

KW - STEM-CELLS

KW - HEPATOCYTES

KW - DIFFERENTIATION

KW - CHOLANGIOCYTES

KW - FIBROSIS

KW - GROWTH

KW - EXPRESSION

KW - SIGNALS

U2 - 10.1016/j.gendis.2020.07.016

DO - 10.1016/j.gendis.2020.07.016

M3 - Review article

SN - 2352-4820

VL - 8

SP - 623

EP - 628

JO - Genes & diseases

JF - Genes & diseases

IS - 5

ER -