Regional distribution of slow-twitch muscle fibers after reinnervation in adult rat hindlimb muscles

LC Wang*, S Copray, N Brouwer, MF Meek, D Kernell

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    23 Citations (Scopus)

    Abstract

    the knee. Following a survival time of 21 weeks, five muscles were removed from both lower hindlimbs after determining their intra-limb positions. In each muscle, cryostat sections from seven equidistant proximo-distal levels were stained for myofibrillar ATPase. Intramuscular positions were determined for all slow-twitch type I fibers. Within each muscle, type I fibers were heterogeneously distributed, and the direction of type I fiber accumulation was, on average, almost identical in reinnervated muscles and contralateral controls. Furthermore, as in controls, a proximo-distal decline of type I fiber density was found in reinnervated muscles. Compared to contralateral controls, reinnervated muscles consistently showed a very high number of type I fibers at close interfiber distances, indicating respecification of muscle fiber types by the ingrowing nerve fibers. The results suggest that slow-twitch motor axons preferentially grew back toward the original slow-twitch muscle regions. (C) 2002 Wiley Periodicals, Inc.

    Original languageEnglish
    Pages (from-to)805-815
    Number of pages11
    JournalMUSCLE & NERVE
    Volume25
    Issue number6
    DOIs
    Publication statusPublished - Jun-2002
    Event29th Annual Meeting of the Society-for-Neuroscience -
    Duration: 23-Oct-199928-Oct-1999

    Keywords

    • muscle fiber type grouping
    • rat
    • reinnervation
    • skeletal muscle
    • slow-twitch muscle fibers
    • topographical organization
    • CAT TIBIALIS ANTERIOR
    • INCOMPLETE NEURAL-CONTROL
    • MOTOR-UNIT PROPERTIES
    • SELECTIVE REINNERVATION
    • LATERAL GASTROCNEMIUS
    • SELF-REINNERVATION
    • SKELETAL-MUSCLES
    • THYROID-HORMONE
    • SOLEUS MUSCLES
    • NERVE REPAIR

    Fingerprint

    Dive into the research topics of 'Regional distribution of slow-twitch muscle fibers after reinnervation in adult rat hindlimb muscles'. Together they form a unique fingerprint.

    Cite this