Abstract
the knee. Following a survival time of 21 weeks, five muscles were removed from both lower hindlimbs after determining their intra-limb positions. In each muscle, cryostat sections from seven equidistant proximo-distal levels were stained for myofibrillar ATPase. Intramuscular positions were determined for all slow-twitch type I fibers. Within each muscle, type I fibers were heterogeneously distributed, and the direction of type I fiber accumulation was, on average, almost identical in reinnervated muscles and contralateral controls. Furthermore, as in controls, a proximo-distal decline of type I fiber density was found in reinnervated muscles. Compared to contralateral controls, reinnervated muscles consistently showed a very high number of type I fibers at close interfiber distances, indicating respecification of muscle fiber types by the ingrowing nerve fibers. The results suggest that slow-twitch motor axons preferentially grew back toward the original slow-twitch muscle regions. (C) 2002 Wiley Periodicals, Inc.
Original language | English |
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Pages (from-to) | 805-815 |
Number of pages | 11 |
Journal | MUSCLE & NERVE |
Volume | 25 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun-2002 |
Event | 29th Annual Meeting of the Society-for-Neuroscience - Duration: 23-Oct-1999 → 28-Oct-1999 |
Keywords
- muscle fiber type grouping
- rat
- reinnervation
- skeletal muscle
- slow-twitch muscle fibers
- topographical organization
- CAT TIBIALIS ANTERIOR
- INCOMPLETE NEURAL-CONTROL
- MOTOR-UNIT PROPERTIES
- SELECTIVE REINNERVATION
- LATERAL GASTROCNEMIUS
- SELF-REINNERVATION
- SKELETAL-MUSCLES
- THYROID-HORMONE
- SOLEUS MUSCLES
- NERVE REPAIR