Regional localization of halopemide, a new psychotropic agent, in the rat brain

A.J.M. Loonen, I. Van Wijngaarden, P.A.J. Janssen, W. Soudijn

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    Abstract

    Halopemide is a new psychotropic agent, structurally related to the neuroleptics of the butyrophenone type, but with a different pharmacological and clinical profile. The concentration of halopemide in the rat brain is about 10 times less than that of R 29800, its chemical congener and of spiperone, both typical neuroleptics. In the pituitary gland, however, the levels are the same. The distribution profile of halopemide in rat brain deviates from that of neuroleptics. The highest level of halopemide is found in septal and thalamic areas whereas the neuroleptics are concentrated in the caudate nucleus, the nucleus accumbens and the tuberculum olfactorium. Subcellular distribution experiments show that in the caudate nucleus halopemide is far less particle-bound than are the neuroleptic agents.
    Original languageEnglish
    Pages (from-to)403-408
    Number of pages6
    JournalEuropean Journal of Pharmacology
    Volume50
    Issue number4
    DOIs
    Publication statusPublished - 22-Apr-1978

    Keywords

    • halopemide
    • halopemide h 3
    • r 29800 h 3
    • ro 29800
    • spiperone
    • spiperone h 3
    • unclassified drug
    • animal experiment
    • article
    • brain
    • central nervous system
    • drug comparison
    • drug distribution
    • pharmacokinetics
    • rat
    • structure activity relation
    • subcutaneous drug administration

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