Abstract
The invention relates to the field of chemical derivatization. In particular, it relates to modified aminoglycosides, such as antibiotics, and methods for producing them. Provided is a method for the regioselective diazotation of a desoxy-streptamine- substituted aminoglycoside, comprising contacting the aminoglycoside with imidazole- -sulfonyl azide hydrochloride under neutral p H conditions to allow for the conversion of the single amine group at the 3-C position of the desoxy-streptamine ring into an azide group. Also provided are novel antibiotic compounds.
| Original language | English |
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| Patent number | WO2013191550 |
| Priority date | 20/06/2012 |
| Filing date | 20/06/2013 |
| Publication status | Published - 27-Dec-2013 |