Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona

Krishnendu Saha, Mehran Rahimi, Mandieh Yazdani, Sung Tae Kim, Daniel F. Moyano, Singyuk Hou, Ridhha Das, Rubul Mout, Farhad Rezaee, Morteza Mahmoudi, Vincent M. Rotello

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Abstract

Using a family of cationic gold nanoparticles (NPs) with similar size and charge, we demonstrate that proper surface engineering can control the nature and identity of protein corona in physiological serum conditions. The protein coronas were highly dependent on the hydrophobicity and arrangement of chemical motifs on NP surface. The NPs were uptaken in macrophages in a corona-dependent manner, predominantly through recognition of specific complement proteins in the NP corona. Taken together, this study shows that surface functionality can be used to tune the protein corona formed on NP surface, dictating the interaction of NPs with macrophages.

Original languageEnglish
Pages (from-to)4421-4430
Number of pages10
JournalAcs Nano
Volume10
Issue number4
DOIs
Publication statusPublished - Apr-2016

Keywords

  • gold nanoparticles
  • protein corona
  • macrophages
  • complement system
  • surface functionality
  • IRON-OXIDE NANOPARTICLES
  • GOLD NANOPARTICLES
  • C4B-BINDING PROTEIN
  • DENSITY-LIPOPROTEIN
  • APOPTOTIC CELLS
  • CELLULAR UPTAKE
  • DELIVERY
  • INTERFACE
  • SIZE
  • COAGULATION

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