Relation between muscle and brain activity during isometric contractions of the first dorsal interosseus muscle

Hiske van Duinen*, Remco Renken, Natasha M. Maurits, Inge Zijdewind

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    63 Citations (Scopus)

    Abstract

    We studied the relationship between muscle activity (electromyography, EMG), force, and brain activity during isometric contractions of the index finger, on a group and individual level. Ten subjects contracted their right or left index finger at 5, 15, 30, 50, and 70% of their maximal force. Subjects received visual feedback of the produced force. We focused our analysis on brain activation that correlated with EMG. Brain activity of specific anatomical areas (region-of-interest analysis, ROI) was quantified and correlated with EMG activity. Furthermore, we tried to distinguish between brain areas in which activity was modulated by the amount of EMG and areas that were active during the task but in which the activity was not modulated. Therefore, we used two regressors simultaneously: (1) the produced EMG and (2) the task (a categorical regressor). As expected, activity in the motor areas (contralateral sensorimotor cortex, premotor areas, and ipsilateral cerebellum) strongly correlated with the amount of EMG. In contrast, activity in frontal and parietal areas (inferior part of the right precentral sulcus, ipsilateral supramarginal gyrus, bilateral inferior parietal lobule, bilateral putamen, and insular cortex) correlated with activation per se, independently of the amount of EMG. Activity in these areas was equal during contractions of the right or left index finger. We suppose that these areas are more involved in higher order motor processes during the preparatory phase or monitoring feedback mechanisms. Furthermore, our ROI analysis showed that muscle and brain activity strongly correlate in traditional motor areas, both at group and at subject level.

    Original languageEnglish
    Pages (from-to)281-299
    Number of pages19
    JournalHuman brain mapping
    Volume29
    Issue number3
    DOIs
    Publication statusPublished - Mar-2008

    Keywords

    • force
    • EMG
    • fMRI
    • regression analysis
    • POSITRON EMISSION TOMOGRAPHY
    • PRIMARY MOTOR CORTEX
    • FUNCTIONAL MRI
    • MAGNETIC STIMULATION
    • FINGER MOVEMENT
    • PARIETAL CORTEX
    • FORCE
    • FMRI
    • ACTIVATION
    • ATTENTION

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