Relation between soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I and incident atrial fibrillation

Michel Rienstra; Xiaoyan Yin; Martin G. Larson; Joao D. Fontes; Jared W. Magnani; David D. McManus; Elizabeth L. McCabe; Erin E. Coglianese; Michael Amponsah; Jennifer E. Ho; James L. Januzzi; Kai C. Wollert; Michael G. Fradley; Ramachandran S. Vasan; Patrick T. Ellinor; Thomas J. Wang; Emelia J. Benjamin

doi:10.1016/j.ahj.2013.10.003

Relation between soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I and incident atrial fibrillation

Michel Rienstra, Xiaoyan Yin, Martin G. Larson, Joao D. Fontes, Jared W. Magnani, David D. McManus, Elizabeth L. McCabe, Erin E. Coglianese, Michael Amponsah, Jennifer E. Ho, James L. Januzzi, Kai C. Wollert, Michael G. Fradley, Ramachandran S. Vasan, Patrick T. Ellinor, Thomas J. Wang, Emelia J. Benjamin

Cardiovascular Centre (CVC)

Research output: Contribution to journal › Article › Academic › peer-review

89 Citations (Scopus)

Abstract

BACKGROUND: We investigated whether circulating concentrations of soluble ST2, growth differentiation factor-15 (GDF-15), and high-sensitivity troponin I (hsTnI) are associated with incident atrial fibrillation (AF) and whether these biomarkers improve current risk prediction models including AF risk factors, B-type natriuretic peptide (BNP), and C-reactive protein (CRP).

METHODS: We studied the relation between soluble ST2, GDF-15, and hsTnI and development of AF in Framingham Heart Study participants without prevalent AF. We used Cox proportional hazard regression analysis to examine the relation of incident AF during a 10-year follow-up period with each biomarker. We adjusted for standard AF clinical risk factors, BNP, and CRP.

RESULTS: The mean age of the 3,217 participants was 59 ± 10 years, and 54% were women. During a 10-year follow-up, 242 participants developed AF. In age- and sex-adjusted models, GDF-15 and hsTnI were associated with risk of incident AF; however, after including the AF risk factors and BNP and CRP, only hsTnI was significantly associated with AF (hazard ratio per 1 SD of loge hsTnI, 1.12, 95% CI 1.00-1.26, P = .045). The c statistic of the base model including AF risk factors, BNP, and CRP was 0.803 (95% CI 0.777-0.830) and did not improve by adding individual or all 3 biomarkers. None of the discrimination and reclassification statistics were significant compared with the base model.

CONCLUSION: In a community-based cohort, circulating hsTnI concentrations were associated with incident AF. None of the novel biomarkers evaluated improved AF risk discrimination or reclassification beyond standard clinical AF risk factors and biomarkers.

Original language	English
Pages (from-to)	109-115.e2
Number of pages	9
Journal	American Heart Journal
Volume	167
Issue number	1
DOIs	https://doi.org/10.1016/j.ahj.2013.10.003
Publication status	Published - Jan-2014

Keywords

CHRONIC HEART-FAILURE
FAMILY-MEMBER ST2
RISK-FACTORS
MYOCARDIAL-INFARCTION
MULTIPLE BIOMARKERS
GENERAL-POPULATION
CARDIAC STRUCTURE
ISCHEMIC-STROKE
MORTALITY RISK
SERUM-LEVELS

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Rienstra, M., Yin, X., Larson, M. G., Fontes, J. D., Magnani, J. W., McManus, D. D., McCabe, E. L., Coglianese, E. E., Amponsah, M., Ho, J. E., Januzzi, J. L., Wollert, K. C., Fradley, M. G., Vasan, R. S., Ellinor, P. T., Wang, T. J., & Benjamin, E. J. (2014). Relation between soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I and incident atrial fibrillation. American Heart Journal, 167(1), 109-115.e2. https://doi.org/10.1016/j.ahj.2013.10.003

@article{482f4730480f4b8aa3fdc0a49cd3353e,

title = "Relation between soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I and incident atrial fibrillation",

abstract = "BACKGROUND: We investigated whether circulating concentrations of soluble ST2, growth differentiation factor-15 (GDF-15), and high-sensitivity troponin I (hsTnI) are associated with incident atrial fibrillation (AF) and whether these biomarkers improve current risk prediction models including AF risk factors, B-type natriuretic peptide (BNP), and C-reactive protein (CRP).METHODS: We studied the relation between soluble ST2, GDF-15, and hsTnI and development of AF in Framingham Heart Study participants without prevalent AF. We used Cox proportional hazard regression analysis to examine the relation of incident AF during a 10-year follow-up period with each biomarker. We adjusted for standard AF clinical risk factors, BNP, and CRP.RESULTS: The mean age of the 3,217 participants was 59 ± 10 years, and 54% were women. During a 10-year follow-up, 242 participants developed AF. In age- and sex-adjusted models, GDF-15 and hsTnI were associated with risk of incident AF; however, after including the AF risk factors and BNP and CRP, only hsTnI was significantly associated with AF (hazard ratio per 1 SD of loge hsTnI, 1.12, 95% CI 1.00-1.26, P = .045). The c statistic of the base model including AF risk factors, BNP, and CRP was 0.803 (95% CI 0.777-0.830) and did not improve by adding individual or all 3 biomarkers. None of the discrimination and reclassification statistics were significant compared with the base model.CONCLUSION: In a community-based cohort, circulating hsTnI concentrations were associated with incident AF. None of the novel biomarkers evaluated improved AF risk discrimination or reclassification beyond standard clinical AF risk factors and biomarkers.",

keywords = "CHRONIC HEART-FAILURE, FAMILY-MEMBER ST2, RISK-FACTORS, MYOCARDIAL-INFARCTION, MULTIPLE BIOMARKERS, GENERAL-POPULATION, CARDIAC STRUCTURE, ISCHEMIC-STROKE, MORTALITY RISK, SERUM-LEVELS",

author = "Michel Rienstra and Xiaoyan Yin and Larson, {Martin G.} and Fontes, {Joao D.} and Magnani, {Jared W.} and McManus, {David D.} and McCabe, {Elizabeth L.} and Coglianese, {Erin E.} and Michael Amponsah and Ho, {Jennifer E.} and Januzzi, {James L.} and Wollert, {Kai C.} and Fradley, {Michael G.} and Vasan, {Ramachandran S.} and Ellinor, {Patrick T.} and Wang, {Thomas J.} and Benjamin, {Emelia J.}",

note = "{\textcopyright} 2014.",

year = "2014",

month = jan,

doi = "10.1016/j.ahj.2013.10.003",

language = "English",

volume = "167",

pages = "109--115.e2",

journal = "American Heart Journal",

issn = "0002-8703",

publisher = "MOSBY-ELSEVIER",

number = "1",

}

Rienstra, M, Yin, X, Larson, MG, Fontes, JD, Magnani, JW, McManus, DD, McCabe, EL, Coglianese, EE, Amponsah, M, Ho, JE, Januzzi, JL, Wollert, KC, Fradley, MG, Vasan, RS, Ellinor, PT, Wang, TJ & Benjamin, EJ 2014, 'Relation between soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I and incident atrial fibrillation', American Heart Journal, vol. 167, no. 1, pp. 109-115.e2. https://doi.org/10.1016/j.ahj.2013.10.003

TY - JOUR

T1 - Relation between soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I and incident atrial fibrillation

AU - Rienstra, Michel

AU - Yin, Xiaoyan

AU - Larson, Martin G.

AU - Fontes, Joao D.

AU - Magnani, Jared W.

AU - McManus, David D.

AU - McCabe, Elizabeth L.

AU - Coglianese, Erin E.

AU - Amponsah, Michael

AU - Ho, Jennifer E.

AU - Januzzi, James L.

AU - Wollert, Kai C.

AU - Fradley, Michael G.

AU - Vasan, Ramachandran S.

AU - Ellinor, Patrick T.

AU - Wang, Thomas J.

AU - Benjamin, Emelia J.

PY - 2014/1

Y1 - 2014/1

N2 - BACKGROUND: We investigated whether circulating concentrations of soluble ST2, growth differentiation factor-15 (GDF-15), and high-sensitivity troponin I (hsTnI) are associated with incident atrial fibrillation (AF) and whether these biomarkers improve current risk prediction models including AF risk factors, B-type natriuretic peptide (BNP), and C-reactive protein (CRP).METHODS: We studied the relation between soluble ST2, GDF-15, and hsTnI and development of AF in Framingham Heart Study participants without prevalent AF. We used Cox proportional hazard regression analysis to examine the relation of incident AF during a 10-year follow-up period with each biomarker. We adjusted for standard AF clinical risk factors, BNP, and CRP.RESULTS: The mean age of the 3,217 participants was 59 ± 10 years, and 54% were women. During a 10-year follow-up, 242 participants developed AF. In age- and sex-adjusted models, GDF-15 and hsTnI were associated with risk of incident AF; however, after including the AF risk factors and BNP and CRP, only hsTnI was significantly associated with AF (hazard ratio per 1 SD of loge hsTnI, 1.12, 95% CI 1.00-1.26, P = .045). The c statistic of the base model including AF risk factors, BNP, and CRP was 0.803 (95% CI 0.777-0.830) and did not improve by adding individual or all 3 biomarkers. None of the discrimination and reclassification statistics were significant compared with the base model.CONCLUSION: In a community-based cohort, circulating hsTnI concentrations were associated with incident AF. None of the novel biomarkers evaluated improved AF risk discrimination or reclassification beyond standard clinical AF risk factors and biomarkers.

AB - BACKGROUND: We investigated whether circulating concentrations of soluble ST2, growth differentiation factor-15 (GDF-15), and high-sensitivity troponin I (hsTnI) are associated with incident atrial fibrillation (AF) and whether these biomarkers improve current risk prediction models including AF risk factors, B-type natriuretic peptide (BNP), and C-reactive protein (CRP).METHODS: We studied the relation between soluble ST2, GDF-15, and hsTnI and development of AF in Framingham Heart Study participants without prevalent AF. We used Cox proportional hazard regression analysis to examine the relation of incident AF during a 10-year follow-up period with each biomarker. We adjusted for standard AF clinical risk factors, BNP, and CRP.RESULTS: The mean age of the 3,217 participants was 59 ± 10 years, and 54% were women. During a 10-year follow-up, 242 participants developed AF. In age- and sex-adjusted models, GDF-15 and hsTnI were associated with risk of incident AF; however, after including the AF risk factors and BNP and CRP, only hsTnI was significantly associated with AF (hazard ratio per 1 SD of loge hsTnI, 1.12, 95% CI 1.00-1.26, P = .045). The c statistic of the base model including AF risk factors, BNP, and CRP was 0.803 (95% CI 0.777-0.830) and did not improve by adding individual or all 3 biomarkers. None of the discrimination and reclassification statistics were significant compared with the base model.CONCLUSION: In a community-based cohort, circulating hsTnI concentrations were associated with incident AF. None of the novel biomarkers evaluated improved AF risk discrimination or reclassification beyond standard clinical AF risk factors and biomarkers.

KW - CHRONIC HEART-FAILURE

KW - FAMILY-MEMBER ST2

KW - RISK-FACTORS

KW - MYOCARDIAL-INFARCTION

KW - MULTIPLE BIOMARKERS

KW - GENERAL-POPULATION

KW - CARDIAC STRUCTURE

KW - ISCHEMIC-STROKE

KW - MORTALITY RISK

KW - SERUM-LEVELS

U2 - 10.1016/j.ahj.2013.10.003

DO - 10.1016/j.ahj.2013.10.003

M3 - Article

C2 - 24332149

SN - 0002-8703

VL - 167

SP - 109-115.e2

JO - American Heart Journal

JF - American Heart Journal

IS - 1

ER -

Relation between soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I and incident atrial fibrillation

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