Relation between the solubility of proteins in aqueous solutions and the second virial coefficient of the solution

C Haas, J Drenth*, WW Wilson

*Corresponding author for this work

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    152 Citations (Scopus)

    Abstract

    Tn recent publications it was pointed out that there is a correlation between the observed values of the solubility of proteins in aqueous solutions and the second virial coefficient of the solution. In this paper we give a theoretical explanation of this relation. The derived theoretical expression describes the experimentally observed relation between solubility and virial coefficient quite accurately. It is concluded that a variation of the crystallization conditions has little effect on the anisotropy or the range of the interactions between the protein molecules. Analysis of the data for lysozyme indicates a strong anisotropy of the interactions between the molecules.

    Original languageEnglish
    Pages (from-to)2808-2811
    Number of pages4
    JournalJournal of Physical Chemistry B
    Volume103
    Issue number14
    Publication statusPublished - 8-Apr-1999

    Keywords

    • PHASE-SEPARATION
    • FLUID

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