Relationship between Circulating PCSK9 and Markers of Subclinical Atherosclerosis-The IMPROVE Study

IMPROVE Study Grp, Daniela Coggi, Beatrice Frigerio, Alice Bonomi, Massimiliano Ruscica, Nicola Ferri, Daniela Sansaro, Alessio Ravani, Palma Ferrante, Manuela Damigella, Fabrizio Veglia, Nicolo Capra, Maria Giovanna Lupo, Chiara Macchi, Kai Savonen, Angela Silveira, Sudhir Kurl, Philippe Giral, Matteo Pirro, Rona Juliette StrawbridgeBruna Gigante, Andries Jan Smit, Elena Tremoli, Mauro Amato, Damiano Baldassarre*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
43 Downloads (Pure)

Abstract

(1) Background and purpose: circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) is one of the key regulators of cholesterol metabolism. Despite this, its role as a player in atherosclerosis development is still matter of debate. Here, we investigated the relationships between this protein and several markers of subclinical atherosclerosis. (2) Methods: the IMPROVE study enrolled 3703 European subjects (54-79 years; 48% men; with >= 3 vascular risk factors), asymptomatic for cardiovascular diseases. PCSK9 levels were measured by ELISA. B-mode ultrasound was used to measure markers of carotid subclinical atherosclerosis. (3) Results: in the crude analysis, PCSK9 levels were associated with several baseline measures of carotid intima-media thickness (cIMT) (all p < 0.0001); with cIMT change over time (Fastest-IMTmax-progr) (p = 0.01); with inter-adventitia common carotid artery diameter (ICCAD) (p < 0.0001); and with the echolucency (Grey Scale Median; GSM) of both carotid plaque and plaque-free common carotid IMT (both p < 0.0001). However, after adjustment for age, sex, latitude, and pharmacological treatment, all the afore-mentioned correlations were no longer statistically significant. The lack of correlation was also observed after stratification for sex, latitude, and pharmacological treatments. (4) Conclusions: in subjects who are asymptomatic for cardiovascular diseases, PCSK9 plasma levels do not correlate with vascular damage and/or subclinical atherosclerosis of extracranial carotid arteries.

Original languageEnglish
Article number841
Number of pages11
JournalBiomedicines
Volume9
Issue number7
DOIs
Publication statusPublished - 19-Jul-2021

Keywords

  • PCSK9
  • subclinical atherosclerosis
  • carotid artery
  • intima-media thickness
  • echolucency
  • SUBTILISIN/KEXIN TYPE 9
  • INTIMA-MEDIA THICKNESS
  • CAROTID-ARTERY
  • EUROPEAN POPULATION
  • CARDIOVASCULAR RISK
  • VASCULAR EVENTS
  • ASSOCIATION
  • PLAQUES
  • PLASMA
  • PREDICTORS

Fingerprint

Dive into the research topics of 'Relationship between Circulating PCSK9 and Markers of Subclinical Atherosclerosis-The IMPROVE Study'. Together they form a unique fingerprint.

Cite this