Relationship between gut microbiota and circulating metabolites in population-based cohorts

Dina Vojinovic*, Djawad Radjabzadeh, Alexander Kurilshikov, Najaf Amin, Cisca Wijmenga, Lude Franke, M Arfan Ikram, Andre G Uitterlinden, Alexandra Zhernakova, Jingyuan Fu, Robert Kraaij, Cornelia M van Duijn

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Gut microbiota has been implicated in major diseases affecting the human population and has also been linked to triglycerides and high-density lipoprotein levels in the circulation. Recent development in metabolomics allows classifying the lipoprotein particles into more details. Here, we examine the impact of gut microbiota on circulating metabolites measured by Nuclear Magnetic Resonance technology in 2309 individuals from the Rotterdam Study and the LifeLines-DEEP cohort. We assess the relationship between gut microbiota and metabolites by linear regression analysis while adjusting for age, sex, body-mass index, technical covariates, medication use, and multiple testing. We report an association of 32 microbial families and genera with very-low-density and high-density subfractions, serum lipid measures, glycolysis-related metabolites, ketone bodies, amino acids, and acute-phase reaction markers. These observations provide insights into the role of microbiota in host metabolism and support the potential of gut microbiota as a target for therapeutic and preventive interventions.

Original languageEnglish
Article number5813
Number of pages7
JournalNature Communications
Volume10
Issue number1
DOIs
Publication statusPublished - 20-Dec-2019

Keywords

  • DENSITY-LIPOPROTEIN
  • HOST GENETICS
  • RISK
  • DISEASE
  • GLYCOPROTEINS
  • ROTTERDAM
  • PARTICLES
  • RELEVANCE
  • PROFILES
  • DATABASE

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