TY - JOUR
T1 - Relationship between left ventricular dysfunction and depression following myocardial infarction
T2 - data from the MIND-IT
AU - van Melle, J P
AU - de Jonge, P
AU - Ormel, J
AU - Crijns, H J G M
AU - van Veldhuisen, D J
AU - Honig, A
AU - Schene, A H
AU - van den Berg, M P
AU - MIND-IT Investigators
N1 - Article 2
PY - 2005/12
Y1 - 2005/12
N2 - Aims Depression in patients following myocardial infarction (MI) is associated with an increased risk of mortality, but this association may be confounded by cardiac disease severity. We explored the relationship between left ventricular ejection fraction (LVEF) and depression in MI patients. Methods and results In the Myocardial Infarction and Depression - Intervention Trial (MIND- IT), 1989 MI patients were assessed for depressive symptoms [Beck Depression Inventory (BDI) t 0, 3, 6, 9, and 12 months post- MI]. Patients with BDI score >= 10 were assessed for the presence of International Classification of Diseases, 10th revision (ICD- 10) depressive disorder (t 3, 6, 9, and 12 months post- MI). Patients were divided into categories according to their LVEF during hospitalization, i. e. LVEF,30%, LVEF 30 - 45%, LVEF 45 - 60%, and LVEF >= 60%. During hospitalization, presence of depressive symptoms was higher in patients with LV dysfunction. A relationship was found between LVEF and ICD- 10 depressive disorder, i. e. a lower LVEF was associated with a higher rate of depression from 3 - 12 months post- MI (P <0.01). Levels of LVEF inversely correlated with the BDI score at 3 months post- MI. Associations persisted after adjustment for demographics, risk factors for coronary artery disease, co- morbidity, Killip class, and baseline BDI score. Conclusion In MI patients, the rate of depression and the severity of depressive symptoms are significantly related to the severity of LV dysfunction. The association between depression and LV dysfunction must be acknowledged when evaluating the prognostic effects of depression in cardiac patients.
AB - Aims Depression in patients following myocardial infarction (MI) is associated with an increased risk of mortality, but this association may be confounded by cardiac disease severity. We explored the relationship between left ventricular ejection fraction (LVEF) and depression in MI patients. Methods and results In the Myocardial Infarction and Depression - Intervention Trial (MIND- IT), 1989 MI patients were assessed for depressive symptoms [Beck Depression Inventory (BDI) t 0, 3, 6, 9, and 12 months post- MI]. Patients with BDI score >= 10 were assessed for the presence of International Classification of Diseases, 10th revision (ICD- 10) depressive disorder (t 3, 6, 9, and 12 months post- MI). Patients were divided into categories according to their LVEF during hospitalization, i. e. LVEF,30%, LVEF 30 - 45%, LVEF 45 - 60%, and LVEF >= 60%. During hospitalization, presence of depressive symptoms was higher in patients with LV dysfunction. A relationship was found between LVEF and ICD- 10 depressive disorder, i. e. a lower LVEF was associated with a higher rate of depression from 3 - 12 months post- MI (P <0.01). Levels of LVEF inversely correlated with the BDI score at 3 months post- MI. Associations persisted after adjustment for demographics, risk factors for coronary artery disease, co- morbidity, Killip class, and baseline BDI score. Conclusion In MI patients, the rate of depression and the severity of depressive symptoms are significantly related to the severity of LV dysfunction. The association between depression and LV dysfunction must be acknowledged when evaluating the prognostic effects of depression in cardiac patients.
KW - left ventricular ejection fraction
KW - myocardial infarction
KW - depression
KW - risk factors
KW - CONGESTIVE-HEART-FAILURE
KW - QUALITY-OF-LIFE
KW - MORTALITY
KW - PROGNOSIS
KW - SYMPTOMS
KW - RISK
KW - ANXIETY
KW - PREDICTORS
KW - ASSOCIATION
KW - PREVALENCE
U2 - 10.1093/eurheartj/ehi480
DO - 10.1093/eurheartj/ehi480
M3 - Article
SN - 0195-668X
VL - 26
SP - 2650
EP - 2656
JO - European Heart Journal
JF - European Heart Journal
IS - 24
ER -