Reliability and validity of the International Cooperative Ataxia Rating Scale: a study in 156 spinocerebellar ataxia patients

Tanja Schmitz-Hübsch; Sophie Tezenas du Montcel; Laszlo Baliko; Sylvia Boesch; Sara Bonato; Roberto Fancellu; Paola Giunti; Christoph Globas; Jun-Suk Kang; Berry Kremer; Caterina Mariotti; Bela Melegh; Maryla Rakowicz; Rafal Rola; Sylvie Romano; Lodger Schöls; Sandra Szymanski; Bart P C van de Warrenburg; Elzbieta Zdzienicka; Alexandra Dürr; Thomas Klockgether

doi:10.1002/mds.20781

Reliability and validity of the International Cooperative Ataxia Rating Scale: a study in 156 spinocerebellar ataxia patients

Tanja Schmitz-Hübsch, Sophie Tezenas du Montcel, Laszlo Baliko, Sylvia Boesch, Sara Bonato, Roberto Fancellu, Paola Giunti, Christoph Globas, Jun-Suk Kang, Berry Kremer, Caterina Mariotti, Bela Melegh, Maryla Rakowicz, Rafal Rola, Sylvie Romano, Lodger Schöls, Sandra Szymanski, Bart P C van de Warrenburg, Elzbieta Zdzienicka, Alexandra DürrThomas Klockgether

Research output: Contribution to journal › Article › Academic › peer-review

143 Citations (Scopus)

Abstract

To evaluate the efficacy of treatments in spinocerebellar ataxias (SCAs), appropriate clinical scales are required. This study evaluated metric properties of the International Cooperative Ataxia Rating Scale (ICARS) in 156 SCA patients and 8 controls. ICARS was found to be a reliable scale satisfying accepted criteria for interrater reliability, test-retest reliability, and internal consistency. Although validity testing was limited, we found evidence of validity of ICARS when ataxia disease stages and Barthel index were used as external criteria. On the other hand, our study revealed two major problems associated with the use of ICARS. First, the redundant and overlapping nature of several items gave rise to a considerable number of contradictory ratings. Second, a factorial analysis showed that the rating results were determined by four different factors that did not coincide with the ICARS subscales, thus questioning the justification of ICARS subscore analysis in clinical trials.

Original language	English
Pages (from-to)	699-704
Number of pages	6
Journal	Movement Disorders
Volume	21
Issue number	5
DOIs	https://doi.org/10.1002/mds.20781
Publication status	Published - May-2006
Externally published	Yes

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Analysis of Variance
Disability Evaluation
Female
Humans
International Cooperation
Male
Middle Aged
Psychometrics
Reproducibility of Results
Sensitivity and Specificity
Severity of Illness Index
Spinocerebellar Ataxias
Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

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Schmitz-Hübsch, T., Tezenas du Montcel, S., Baliko, L., Boesch, S., Bonato, S., Fancellu, R., Giunti, P., Globas, C., Kang, J.-S., Kremer, B., Mariotti, C., Melegh, B., Rakowicz, M., Rola, R., Romano, S., Schöls, L., Szymanski, S., van de Warrenburg, B. P. C., Zdzienicka, E., ... Klockgether, T. (2006). Reliability and validity of the International Cooperative Ataxia Rating Scale: a study in 156 spinocerebellar ataxia patients. Movement Disorders, 21(5), 699-704. https://doi.org/10.1002/mds.20781

@article{e4d81930401c43f280bca233207f62a2,

title = "Reliability and validity of the International Cooperative Ataxia Rating Scale: a study in 156 spinocerebellar ataxia patients",

abstract = "To evaluate the efficacy of treatments in spinocerebellar ataxias (SCAs), appropriate clinical scales are required. This study evaluated metric properties of the International Cooperative Ataxia Rating Scale (ICARS) in 156 SCA patients and 8 controls. ICARS was found to be a reliable scale satisfying accepted criteria for interrater reliability, test-retest reliability, and internal consistency. Although validity testing was limited, we found evidence of validity of ICARS when ataxia disease stages and Barthel index were used as external criteria. On the other hand, our study revealed two major problems associated with the use of ICARS. First, the redundant and overlapping nature of several items gave rise to a considerable number of contradictory ratings. Second, a factorial analysis showed that the rating results were determined by four different factors that did not coincide with the ICARS subscales, thus questioning the justification of ICARS subscore analysis in clinical trials.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Analysis of Variance, Disability Evaluation, Female, Humans, International Cooperation, Male, Middle Aged, Psychometrics, Reproducibility of Results, Sensitivity and Specificity, Severity of Illness Index, Spinocerebellar Ataxias, Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't",

author = "Tanja Schmitz-H{\"u}bsch and {Tezenas du Montcel}, Sophie and Laszlo Baliko and Sylvia Boesch and Sara Bonato and Roberto Fancellu and Paola Giunti and Christoph Globas and Jun-Suk Kang and Berry Kremer and Caterina Mariotti and Bela Melegh and Maryla Rakowicz and Rafal Rola and Sylvie Romano and Lodger Sch{\"o}ls and Sandra Szymanski and {van de Warrenburg}, {Bart P C} and Elzbieta Zdzienicka and Alexandra D{\"u}rr and Thomas Klockgether",

year = "2006",

month = may,

doi = "10.1002/mds.20781",

language = "English",

volume = "21",

pages = "699--704",

journal = "Movement Disorders",

issn = "0885-3185",

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number = "5",

}

Schmitz-Hübsch, T, Tezenas du Montcel, S, Baliko, L, Boesch, S, Bonato, S, Fancellu, R, Giunti, P, Globas, C, Kang, J-S, Kremer, B, Mariotti, C, Melegh, B, Rakowicz, M, Rola, R, Romano, S, Schöls, L, Szymanski, S, van de Warrenburg, BPC, Zdzienicka, E, Dürr, A & Klockgether, T 2006, 'Reliability and validity of the International Cooperative Ataxia Rating Scale: a study in 156 spinocerebellar ataxia patients', Movement Disorders, vol. 21, no. 5, pp. 699-704. https://doi.org/10.1002/mds.20781

TY - JOUR

T1 - Reliability and validity of the International Cooperative Ataxia Rating Scale

T2 - a study in 156 spinocerebellar ataxia patients

AU - Schmitz-Hübsch, Tanja

AU - Tezenas du Montcel, Sophie

AU - Baliko, Laszlo

AU - Boesch, Sylvia

AU - Bonato, Sara

AU - Fancellu, Roberto

AU - Giunti, Paola

AU - Globas, Christoph

AU - Kang, Jun-Suk

AU - Kremer, Berry

AU - Mariotti, Caterina

AU - Melegh, Bela

AU - Rakowicz, Maryla

AU - Rola, Rafal

AU - Romano, Sylvie

AU - Schöls, Lodger

AU - Szymanski, Sandra

AU - van de Warrenburg, Bart P C

AU - Zdzienicka, Elzbieta

AU - Dürr, Alexandra

AU - Klockgether, Thomas

PY - 2006/5

Y1 - 2006/5

N2 - To evaluate the efficacy of treatments in spinocerebellar ataxias (SCAs), appropriate clinical scales are required. This study evaluated metric properties of the International Cooperative Ataxia Rating Scale (ICARS) in 156 SCA patients and 8 controls. ICARS was found to be a reliable scale satisfying accepted criteria for interrater reliability, test-retest reliability, and internal consistency. Although validity testing was limited, we found evidence of validity of ICARS when ataxia disease stages and Barthel index were used as external criteria. On the other hand, our study revealed two major problems associated with the use of ICARS. First, the redundant and overlapping nature of several items gave rise to a considerable number of contradictory ratings. Second, a factorial analysis showed that the rating results were determined by four different factors that did not coincide with the ICARS subscales, thus questioning the justification of ICARS subscore analysis in clinical trials.

AB - To evaluate the efficacy of treatments in spinocerebellar ataxias (SCAs), appropriate clinical scales are required. This study evaluated metric properties of the International Cooperative Ataxia Rating Scale (ICARS) in 156 SCA patients and 8 controls. ICARS was found to be a reliable scale satisfying accepted criteria for interrater reliability, test-retest reliability, and internal consistency. Although validity testing was limited, we found evidence of validity of ICARS when ataxia disease stages and Barthel index were used as external criteria. On the other hand, our study revealed two major problems associated with the use of ICARS. First, the redundant and overlapping nature of several items gave rise to a considerable number of contradictory ratings. Second, a factorial analysis showed that the rating results were determined by four different factors that did not coincide with the ICARS subscales, thus questioning the justification of ICARS subscore analysis in clinical trials.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Analysis of Variance

KW - Disability Evaluation

KW - Female

KW - Humans

KW - International Cooperation

KW - Male

KW - Middle Aged

KW - Psychometrics

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Severity of Illness Index

KW - Spinocerebellar Ataxias

KW - Comparative Study

KW - Journal Article

KW - Multicenter Study

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/mds.20781

DO - 10.1002/mds.20781

M3 - Article

C2 - 16450347

SN - 0885-3185

VL - 21

SP - 699

EP - 704

JO - Movement Disorders

JF - Movement Disorders

IS - 5

ER -

Reliability and validity of the International Cooperative Ataxia Rating Scale: a study in 156 spinocerebellar ataxia patients

Abstract

Keywords

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