Reliability assessment of hyperspectral imaging with the HyperView (TM) system for lower extremity superficial tissue oxygenation in young healthy volunteers

Simone F. Kleiss*, Kirsten F. Ma, Mostafa El Moumni, Richte C. L. Schuurmann, Clark J. Zeebregts, Marieke Haalboom, Reinoud P. H. Bokkers, Jean-Paul P. M. de Vries

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

PURPOSE: Hyperspectral imaging (HSI) is a noninvasive spectroscopy technique for determining superficial tissue oxygenation. The HyperView™ system is a hand-held camera that enables perfusion image acquisition. The evaluation of superficial tissue oxygenation is warranted in the evaluation of patients with peripheral arterial disease. The aim was to determine the reliability of repeated HSI measurements.

METHODS: In this prospective cohort study, HSI was performed on 50 healthy volunteers with a mean age of 26.4 ± 2.5 years, at the lower extremity. Two independent observers performed HSI during two subsequent measurement sessions. Short term test-retest reliability and intra- and inter-observer reliability were determined, and generalizability and decision studies were performed. Transcutaneous oxygen pressure (TcPO2) measurements were also performed.

RESULTS: The short term test-retest reliability was good for the HSI values determined at the lower extremity, ranging from 0.72 to 0.90. Intra- and inter-observer reliability determined at different days were poor to moderate for both HSI (0.24 to 0.71 and 0.30 to 0.58, respectively) and TcPO2 (0.54 and 0.56, and 0.51 and 0.31, respectively). Reliability can be increased to >0.75 by averaging two measurements on different days.

CONCLUSION: This study showed good short term test-retest reliability for HSI measurements, however low intra- and inter-observer reliability was observed for tissue oxygenation measurements with both HSI and TcPO2 performed at separate days in young healthy volunteers. Reliability of HSI can be improved when determined as a mean of two measurements taken on different days.

Original languageEnglish
Pages (from-to)713–723
Number of pages11
JournalJournal of clinical monitoring and computing
Volume36
Early online date12-Apr-2021
DOIs
Publication statusPublished - Jun-2022

Keywords

  • Tissue perfusion
  • Hyperspectral imaging
  • Transcutaneous oxygen pressure
  • Reproducibility of Results
  • Lower extremity
  • Tissue oxygenation

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