Renal oncocytoma with t(5;12;11), der(1)t(1;8) and add(19): ''True'' oncocytoma or chromophobe adenoma?

T Dijkhuizen*, E van den Berg, S Storkel, B deVries, AY vanderVeen, AG vanKessel, B deJong

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    28 Citations (Scopus)

    Abstract

    Renal oncocytomas reveal a considerable (cyto)genetic heterogeneity. At least 2 genetic subsets are currently recognized, characterized by (1) translocations involving breakpoint 11q13 and (2) the combined loss of chromosomes i and X/Y. We present a case of oncocytoma revealing a 3-way translocation involving breakpoint 11q13, a der(1)t(1;8) and an add(19). The der(1) resulted in loss of chromosome I sequences. Using fluorescence in situ hybridization, the 11q13 breakpoint of the present case proved to be slightly different from the one observed previously in 3 cases of renal oncocytoma. Whether the 11q13 breakpoint observed in our case resides in or near another gene remains to be elucidated. (C) 1997 Wiley-Liss, Inc.

    Original languageEnglish
    Pages (from-to)521-524
    Number of pages4
    JournalInternational Journal of Cancer
    Volume73
    Issue number4
    DOIs
    Publication statusPublished - 14-Nov-1997

    Keywords

    • LOW CHROMOSOME-NUMBER
    • CELL CARCINOMA
    • INTERCALATED CELLS
    • DNA
    • MITOCHONDRIAL
    • NEOPLASMS
    • TUMORS

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