Renal response to angiotensin II is blunted in sodium-sensitive normotensive men

Folkert W. Visser*, Arnold H. Boonstra, A. Titia Lely, Fans Boomsma, Gerjan Navis

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Scopus)

Abstract

BACKGROUND

In hypertension, sodium sensitivity (SS) of blood pressure is associated with renal hemodynamic abnormalities related to increased activity of the renal renin-angiotensin aldosterone system (RAAS). The renal mechanisms of SS in normotensives are unknown. Therefore, we studied whether SS is related to renal hemodynamics and renal responsiveness to angiotensin II (Angll) in young healthy adults.

METHODS

Blood pressure (mean arterial pressure (MAP)) and renal function were measured in 34 healthy men after 1-week low-sodium diet (LS; 50 mmol Na+/24 h), 1-week high-sodium diet (HS; 200 mmol Na+/24h), and 1-week HS-ACEi (enalapril 20 mg/day).The responses of effective renal plasma flow (ERPF; I-131-Hippuran clearance) to graded infusion of Angll were assessed during each condition.

RESULTS

The sodium-induced change in MAP ranged from -7to+14mmHg. SS (a sodium-induced increase in MAP > 3 mm Hg) was present in 13 subjects. ERPF was lower in SS subjects during LS and during HS-ACEi. The Angll-induced decrease in ERPF was blunted in SS on LS (-25 +/- 6 vs. -29 +/- 7% in sodium-resistant (SR) subjects, P <0.05) and on HS (-30 +/- 5 vs. -35 +/- 6%, P <0.05).The blunting was corrected by angiotensin-converting enzyme inhibitors (ACE) (-36 +/- 6 vs. -37 +/- 7%).

CONCLUSION

SS normotensive subjects have a blunted renal response to exogenous Angll. This is ameliorated by ACE, supporting a role for inappropriately high intrarenal RAAS activity. As these findings cannot be attributed to subclinical renal hypertensive damage, high intrarenal RAAS activity and altered renal hemodynamics may be primary phenomena underlying SS.

Original languageEnglish
Pages (from-to)323-328
Number of pages6
JournalAmerican Journal of Hypertension
Volume21
Issue number3
DOIs
Publication statusPublished - Mar-2008

Keywords

  • SALT-SENSITIVITY
  • ESSENTIAL-HYPERTENSION
  • CONVERTING-ENZYME
  • BLOOD-PRESSURE
  • SYSTEM
  • RECEPTOR
  • HUMANS
  • RISK

Cite this