TY - JOUR
T1 - Repeatability of automated body composition measurement on low dose chest CT in male subjects
AU - NELSON-POP consortium
AU - Bunk, Stijn
AU - Bennink, Edwin
AU - Sidorenkov, Grigory
AU - Gietema, Hester
AU - Groen, Harry
AU - de Bock, Geertruida
AU - de Jong, Pim A.
AU - Vliegenthart, Rozemarijn
AU - Hoesein, Firdaus Mohamed
AU - Aerts, Joachim G.
AU - Cornelissen, Robin
AU - Stadhouders, Ralph
AU - van Rooij, Jeroen G.J.
AU - Trap, Lianne
AU - Nackaerts, Kristiaan
AU - de Wever, Walter
AU - Prokop, Mathias
AU - Schaefer-Prokop, Cornelia
AU - Jacobs, Colin
AU - Antonissen, Noa
AU - Heuvelmans, Marjolein A.
AU - Zhong, Danrong
AU - van der Velden, Nils
AU - Bruins-Slot, Thijs
AU - Downward, George S.
AU - Vermeulen, Roel C.H.
N1 - Publisher Copyright:
© 2026 Bunk et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2026/4
Y1 - 2026/4
N2 - Background: The objective was to determine the most repeatable of three automated body composition methods applied to baseline and short-term follow-up chest CT scans.Methods: Areas of skeletal muscle and subcutaneous adipose tissue (SAT) were analyzed in a 1mm slice close to the aortic arch in a subset of males from the NELSON lung cancer screening trial with baseline and 3–4 month repeat CT scan. We compared three pre-existing machine learning methods we call: truncated field of view (FOV), compensated FOV, and extended FOV, of which the last two can deal with non-overlapping FOV in scans. Repeatability was assessed using Bland-Altman plots and paired T-tests. Results: Of 562 males the median (interquartile range) age was 60.8 (56.3–64.8) years. Mean skeletal muscle areas were similar for truncated (212 cm2) and extended FOV (211 cm2), and slightly lower for compensated FOV (208 cm2) (p<0.001). SAT areas were higher with extended FOV (156 cm2) compared to truncated (132 cm2) and compensated FOV (125 cm2) (p<0.001). A small systematic longitudinal difference in skeletal muscle was observed for extended FOV (mean±SD 1.7±17.3cm2, p=0.017). Limits of agreement for skeletal muscle area were −18.9% to 20.4% for truncated FOV, −11.1% to 11.6% for compensated FOV, and −16.7% to 18.2% for extended FOV. Corresponding values for SAT area were −37.3% to 38.3%,-30.2% to 29.3%, and −29.1% to 29.9%. Conclusion: Extended FOV had the second-most repeatable measurements and was unaffected by FOV cutoff. Compensated FOV was most repeatable, but underestimated SAT.
AB - Background: The objective was to determine the most repeatable of three automated body composition methods applied to baseline and short-term follow-up chest CT scans.Methods: Areas of skeletal muscle and subcutaneous adipose tissue (SAT) were analyzed in a 1mm slice close to the aortic arch in a subset of males from the NELSON lung cancer screening trial with baseline and 3–4 month repeat CT scan. We compared three pre-existing machine learning methods we call: truncated field of view (FOV), compensated FOV, and extended FOV, of which the last two can deal with non-overlapping FOV in scans. Repeatability was assessed using Bland-Altman plots and paired T-tests. Results: Of 562 males the median (interquartile range) age was 60.8 (56.3–64.8) years. Mean skeletal muscle areas were similar for truncated (212 cm2) and extended FOV (211 cm2), and slightly lower for compensated FOV (208 cm2) (p<0.001). SAT areas were higher with extended FOV (156 cm2) compared to truncated (132 cm2) and compensated FOV (125 cm2) (p<0.001). A small systematic longitudinal difference in skeletal muscle was observed for extended FOV (mean±SD 1.7±17.3cm2, p=0.017). Limits of agreement for skeletal muscle area were −18.9% to 20.4% for truncated FOV, −11.1% to 11.6% for compensated FOV, and −16.7% to 18.2% for extended FOV. Corresponding values for SAT area were −37.3% to 38.3%,-30.2% to 29.3%, and −29.1% to 29.9%. Conclusion: Extended FOV had the second-most repeatable measurements and was unaffected by FOV cutoff. Compensated FOV was most repeatable, but underestimated SAT.
UR - https://www.scopus.com/pages/publications/105035968774
U2 - 10.1371/journal.pone.0332004
DO - 10.1371/journal.pone.0332004
M3 - Article
C2 - 41996421
AN - SCOPUS:105035968774
SN - 1932-6203
VL - 21
JO - PLoS ONE
JF - PLoS ONE
IS - 4
M1 - e0332004
ER -