Repeatability of parametric methods for [F-18]florbetapir imaging in Alzheimer's disease and healthy controls: A test-retest study

Sander C. J. Verfaillie*, Sandeep S. Golla, Tessa Timmers, Hayel Tuncell, Chris W. J. van der Weijden, Patrick Schober, Robert C. Schuit, Wiesje M. van der Flier, Albert D. Windhorst, Adriaan A. Lammertsma, Bart N. M. van Berckel, Ronald Boellaard

*Corresponding author for this work

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Abstract

Accumulation of amyloid beta (A beta) is one of the pathological hallmarks of Alzheimer's disease (AD), which can be visualized using [F-18]florbetapir positron emission tomography (PET). The aim of this study was to evaluate various parametric methods and to assess their test-retest (TRT) reliability. Two 90 min dynamic [F-18]florbetapir PET scans, including arterial sampling, were acquired (n = 8 AD patient, n = 8 controls). The following parametric methods were used; (reference:cerebellum); Logan and spectral analysis (SA), receptor parametric mapping (RPM), simplified reference tissue model2 (SRTM2), reference Logan (rLogan) and standardized uptake value ratios (SUVr(50-70)). BPND+1, DVR, V-T and SUVr were compared with corresponding estimates (V-T or DVR) from the plasma input reversible two tissue compartmental (2T4k_V-B) model with corresponding TRT values for 90-scan duration. RPM (r(2) = 0.92; slope = 0.91), Logan (r(2) = 0.95; slope = 0.84) and rLogan (r(2) = 0.94; slope = 0.88), and SRTM2 (r(2) = 0.91; slope = 0.83), SA (r(2) = 0.91; slope = 0.88), SUVr (r(2) = 0.84; slope = 1.16) correlated well with their 2T4k_V-B counterparts. RPM (controls: 1%, AD: 3%), rLogan (controls: 1%, AD: 3%) and SUVr(50-70) (controls: 3%, AD: 8%) showed an excellent TRT reliability. In conclusion, most parametric methods showed excellent performance for [F-18]florbetapir, but RPM and rLogan seem the methods of choice, combining the highest accuracy and best TRT reliability.

Original languageEnglish
Number of pages10
JournalJournal of Cerebral Blood Flow and Metabolism
Early online date22-Apr-2020
DOIs
Publication statusPublished - Apr-2020

Keywords

  • Amyloid PET
  • Alzheimer's disease
  • test-retest design
  • [F-18]florbetapir
  • parametric imaging methods
  • PET quantification
  • POSITRON-EMISSION-TOMOGRAPHY
  • HUMAN BRAIN
  • PET
  • BINDING
  • DEPOSITION
  • MODEL

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