Repetitive transcranial magnetic stimulation over the right dorsolateral prefrontal cortex affects strategic decision-making

M van't Wout*, RS Kahn, AG Sanfey, A Aleman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

139 Citations (Scopus)

Abstract

Although decision-making is typically seen as a rational process, emotions play a role in tasks that include unfairness. Recently, activation in the right dorsolateral prefrontal cortex during offers experienced as unfair in the Ultimatum Game was suggested to subserve goal maintenance in this task. This is restricted to correlational evidence, however, and it remains unclear whether the dorsolateral prefrontal cortex is crucial for strategic decision-making. The present study used repetitive transcranial magnetic stimulation in order to investigate the causal role of the dorsolateral prefrontal cortex in strategic decision-making in the Ultimatum Game. The results showed that repetitive transcranial magnetic stimulation over the right dorsolateral prefrontal cortex resulted in an altered decision-making strategy compared with sham stimulation. We conclude that the dorsolateral prefrontal cortex is causally implicated in strategic decision-making in healthy human study participants.

Original languageEnglish
Pages (from-to)1849-1852
Number of pages4
JournalNeuroreport
Volume16
Issue number16
Publication statusPublished - 7-Nov-2005

Keywords

  • decision-making
  • dorsolateral prefrontal cortex
  • goal-directed behavior
  • human
  • repetitive transcranial magnetic stimulation
  • Ultimatum Game
  • unfairness
  • WORKING-MEMORY
  • ULTIMATUM GAME
  • TASK
  • RTMS
  • PERFORMANCE
  • FAIRNESS
  • BRAIN

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