Reply to Letter to the Editor HEP-20-0593

Reinout L P Roscam Abbing, Folkert Kuipers, Coen C Paulusma, Henkjan J Verkade, Albert K Groen, Ronald P J Oude Elferink, Stan F J van, Irene M. de Graaf*

*Corresponding author for this work

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

20 Downloads (Pure)

Abstract

We sincerely thank Dr. Javitt for his interest in and perspective on our paper (1). He indicates that aspecific effects of Myrcludex B should be considered an explanation for increased biliary cholesterol and phospholipid secretion after Myrcludex B treatment as partial hepatectomy (PH) also leads to an increased contribution of pericentral hepatocytes to bile salt uptake and secretion but biliary cholesterol and phospholipid secretion are not affected. In our opinion, non-specific Myrcludex B-induced activation of canalicular or sinusoidal transporters seems unlikely given the absence of NTCP homology with these transporters and our data from experiments with SR-B1 or ABCG8 null mice. Myrcludex B is an NTCP-specific peptide showing minimal uptake by hepatocytes.

Original languageEnglish
Number of pages2
JournalHepatology
Early online date25-Apr-2020
DOIs
Publication statusPublished - 16-Oct-2020

Cite this