Reply to Letter to the Editor HEP-20-0593

Reinout L P Roscam Abbing; Folkert Kuipers; Coen C Paulusma; Henkjan J Verkade; Albert K Groen; Ronald P J Oude Elferink; Stan F J van; Irene M. de Graaf

doi:10.1002/hep.31291

Reply to Letter to the Editor HEP-20-0593

Reinout L P Roscam Abbing, Folkert Kuipers, Coen C Paulusma, Henkjan J Verkade, Albert K Groen, Ronald P J Oude Elferink, Stan F J van, Irene M. de Graaf^*

^*Corresponding author for this work

Center for Liver, Digestive and Metabolic Diseases (CLDM)

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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Abstract

We sincerely thank Dr. Javitt for his interest in and perspective on our paper (1). He indicates that aspecific effects of Myrcludex B should be considered an explanation for increased biliary cholesterol and phospholipid secretion after Myrcludex B treatment as partial hepatectomy (PH) also leads to an increased contribution of pericentral hepatocytes to bile salt uptake and secretion but biliary cholesterol and phospholipid secretion are not affected. In our opinion, non-specific Myrcludex B-induced activation of canalicular or sinusoidal transporters seems unlikely given the absence of NTCP homology with these transporters and our data from experiments with SR-B1 or ABCG8 null mice. Myrcludex B is an NTCP-specific peptide showing minimal uptake by hepatocytes.

Original language	English
Pages (from-to)	1885-1886
Number of pages	2
Journal	Hepatology
Issue number	5
Early online date	25-Apr-2020
DOIs	https://doi.org/10.1002/hep.31291
Publication status	Published - 1-Nov-2020

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title = "Reply to Letter to the Editor HEP-20-0593",

abstract = "We sincerely thank Dr. Javitt for his interest in and perspective on our paper (1). He indicates that aspecific effects of Myrcludex B should be considered an explanation for increased biliary cholesterol and phospholipid secretion after Myrcludex B treatment as partial hepatectomy (PH) also leads to an increased contribution of pericentral hepatocytes to bile salt uptake and secretion but biliary cholesterol and phospholipid secretion are not affected. In our opinion, non-specific Myrcludex B-induced activation of canalicular or sinusoidal transporters seems unlikely given the absence of NTCP homology with these transporters and our data from experiments with SR-B1 or ABCG8 null mice. Myrcludex B is an NTCP-specific peptide showing minimal uptake by hepatocytes.",

author = "{Roscam Abbing}, {Reinout L P} and Folkert Kuipers and Paulusma, {Coen C} and Verkade, {Henkjan J} and Groen, {Albert K} and {Oude Elferink}, {Ronald P J} and van, {Stan F J} and {de Graaf}, {Irene M.}",

year = "2020",

month = nov,

day = "1",

doi = "10.1002/hep.31291",

language = "English",

pages = "1885--1886",

journal = "Hepatology",

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TY - JOUR

T1 - Reply to Letter to the Editor HEP-20-0593

AU - Roscam Abbing, Reinout L P

AU - Kuipers, Folkert

AU - Paulusma, Coen C

AU - Verkade, Henkjan J

AU - Groen, Albert K

AU - Oude Elferink, Ronald P J

AU - van, Stan F J

AU - de Graaf, Irene M.

PY - 2020/11/1

Y1 - 2020/11/1

N2 - We sincerely thank Dr. Javitt for his interest in and perspective on our paper (1). He indicates that aspecific effects of Myrcludex B should be considered an explanation for increased biliary cholesterol and phospholipid secretion after Myrcludex B treatment as partial hepatectomy (PH) also leads to an increased contribution of pericentral hepatocytes to bile salt uptake and secretion but biliary cholesterol and phospholipid secretion are not affected. In our opinion, non-specific Myrcludex B-induced activation of canalicular or sinusoidal transporters seems unlikely given the absence of NTCP homology with these transporters and our data from experiments with SR-B1 or ABCG8 null mice. Myrcludex B is an NTCP-specific peptide showing minimal uptake by hepatocytes.

AB - We sincerely thank Dr. Javitt for his interest in and perspective on our paper (1). He indicates that aspecific effects of Myrcludex B should be considered an explanation for increased biliary cholesterol and phospholipid secretion after Myrcludex B treatment as partial hepatectomy (PH) also leads to an increased contribution of pericentral hepatocytes to bile salt uptake and secretion but biliary cholesterol and phospholipid secretion are not affected. In our opinion, non-specific Myrcludex B-induced activation of canalicular or sinusoidal transporters seems unlikely given the absence of NTCP homology with these transporters and our data from experiments with SR-B1 or ABCG8 null mice. Myrcludex B is an NTCP-specific peptide showing minimal uptake by hepatocytes.

U2 - 10.1002/hep.31291

DO - 10.1002/hep.31291

M3 - Comment/Letter to the editor

C2 - 32333679

SN - 0270-9139

SP - 1885

EP - 1886

JO - Hepatology

JF - Hepatology

IS - 5

ER -

Reply to Letter to the Editor HEP-20-0593

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