Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study

Dominique S Michaud; Valentina Gallo; Brigitte Schlehofer; Anne Tjønneland; Anja Olsen; Kim Overvad; Christina C Dahm; Rudolf Kaaks; Annekatrin Lukanova; Heiner Boeing; Madlen Schütze; Antonia Trichopoulou; Christina Bamia; Andreas Kyrozis; Carlotta Sacerdote; Claudia Agnoli; Domenico Palli; Rosario Tumino; Amalia Mattiello; H Bas Bueno-de-Mesquita; Martine M Ros; Petra H M Peeters; Carla H van Gils; Eiliv Lund; Kjersti Bakken; Inger T Gram; Aurelio Barricarte; Carmen Navarro; Miren Dorronsoro; Maria José Sánchez; Laudina Rodríguez; Eric J Duell; Göran Hallmans; Beatrice S Melin; Jonas Manjer; Signe Borgquist; Kay-Tee Khaw; Nick Wareham; Naomi E Allen; Konstantinos K Tsilidis; Isabelle Romieu; Sabina Rinaldi; Paolo Vineis; Elio Riboli

doi:10.1158/1055-9965.EPI-10-0447

Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study

Dominique S Michaud
, Valentina Gallo
, Brigitte Schlehofer
, Anne Tjønneland
, Anja Olsen
, Kim Overvad
, Christina C Dahm
, Rudolf Kaaks
, Annekatrin Lukanova
, Heiner Boeing
, Madlen Schütze
, Antonia Trichopoulou
, Christina Bamia
, Andreas Kyrozis
, Carlotta Sacerdote
, Claudia Agnoli
, Domenico Palli
, Rosario Tumino
, Amalia Mattiello
, H Bas Bueno-de-Mesquita

Martine M Ros, Petra H M Peeters, Carla H van Gils, Eiliv Lund, Kjersti Bakken, Inger T Gram, Aurelio Barricarte, Carmen Navarro, Miren Dorronsoro, Maria José Sánchez, Laudina Rodríguez, Eric J Duell, Göran Hallmans, Beatrice S Melin, Jonas Manjer, Signe Borgquist, Kay-Tee Khaw, Nick Wareham, Naomi E Allen, Konstantinos K Tsilidis, Isabelle Romieu, Sabina Rinaldi, Paolo Vineis, Elio Riboli

Research output: Contribution to journal › Article › Academic › peer-review

117 Citations (Scopus)

Abstract

BACKGROUND: The etiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and the risk of glioma and meningioma among women in the European Prospective Investigation into Cancer and Nutrition (EPIC).

METHODS: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma cases were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95% confidence intervals (95% CI).

RESULTS: No associations were observed between glioma or meningioma risk and reproductive factors, including age at menarche, parity, age at first birth, menopausal status, and age at menopause. A higher risk of meningioma was observed among postmenopausal women who were current users of hormone replacement therapy (HR, 1.79; 95% CI, 1.18-2.71) compared with never users. Similarly, current users of oral contraceptives were at higher risk of meningioma than never users (HR, 3.61; 95% CI, 1.75-7.46).

CONCLUSION: Our results do not support a role for estrogens and glioma risk. Use of exogenous hormones, especially current use, seems to increase meningioma risk. However, these findings could be due to diagnostic bias and require confirmation.

IMPACT: Elucidating the role of hormones in brain tumor development has important implications and needs to be further examined using biological measurements.

Original language	English
Pages (from-to)	2562-9
Number of pages	8
Journal	Cancer Epidemiology, Biomarkers & Prevention
Volume	19
Issue number	10
DOIs	https://doi.org/10.1158/1055-9965.EPI-10-0447
Publication status	Published - 2010
Externally published	Yes

Keywords

Brain Neoplasms/epidemiology
Cohort Studies
Contraceptives, Oral/administration & dosage
Europe/epidemiology
Female
Glioma/epidemiology
Hormone Replacement Therapy/adverse effects
Humans
Meningeal Neoplasms/epidemiology
Meningioma/epidemiology
Middle Aged
Pregnancy
Prospective Studies
Reproductive History

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Reproductive Factors and Exogenous Hormone Use in Relation to Risk of Glioma and Meningioma in a Large European Cohort Study
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Michaud, D. S., Gallo, V., Schlehofer, B., Tjønneland, A., Olsen, A., Overvad, K., Dahm, C. C., Kaaks, R., Lukanova, A., Boeing, H., Schütze, M., Trichopoulou, A., Bamia, C., Kyrozis, A., Sacerdote, C., Agnoli, C., Palli, D., Tumino, R., Mattiello, A., ... Riboli, E. (2010). Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study. Cancer Epidemiology, Biomarkers & Prevention, 19(10), 2562-9. https://doi.org/10.1158/1055-9965.EPI-10-0447

@article{5ebea5ee7bbc4da1b6d714b1b1dd097f,

title = "Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study",

abstract = "BACKGROUND: The etiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and the risk of glioma and meningioma among women in the European Prospective Investigation into Cancer and Nutrition (EPIC).METHODS: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma cases were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95\% confidence intervals (95\% CI).RESULTS: No associations were observed between glioma or meningioma risk and reproductive factors, including age at menarche, parity, age at first birth, menopausal status, and age at menopause. A higher risk of meningioma was observed among postmenopausal women who were current users of hormone replacement therapy (HR, 1.79; 95\% CI, 1.18-2.71) compared with never users. Similarly, current users of oral contraceptives were at higher risk of meningioma than never users (HR, 3.61; 95\% CI, 1.75-7.46).CONCLUSION: Our results do not support a role for estrogens and glioma risk. Use of exogenous hormones, especially current use, seems to increase meningioma risk. However, these findings could be due to diagnostic bias and require confirmation.IMPACT: Elucidating the role of hormones in brain tumor development has important implications and needs to be further examined using biological measurements.",

keywords = "Brain Neoplasms/epidemiology, Cohort Studies, Contraceptives, Oral/administration \& dosage, Europe/epidemiology, Female, Glioma/epidemiology, Hormone Replacement Therapy/adverse effects, Humans, Meningeal Neoplasms/epidemiology, Meningioma/epidemiology, Middle Aged, Pregnancy, Prospective Studies, Reproductive History",

author = "Michaud, \{Dominique S\} and Valentina Gallo and Brigitte Schlehofer and Anne Tj{\o}nneland and Anja Olsen and Kim Overvad and Dahm, \{Christina C\} and Rudolf Kaaks and Annekatrin Lukanova and Heiner Boeing and Madlen Sch{\"u}tze and Antonia Trichopoulou and Christina Bamia and Andreas Kyrozis and Carlotta Sacerdote and Claudia Agnoli and Domenico Palli and Rosario Tumino and Amalia Mattiello and Bueno-de-Mesquita, \{H Bas\} and Ros, \{Martine M\} and Peeters, \{Petra H M\} and \{van Gils\}, \{Carla H\} and Eiliv Lund and Kjersti Bakken and Gram, \{Inger T\} and Aurelio Barricarte and Carmen Navarro and Miren Dorronsoro and S{\'a}nchez, \{Maria Jos{\'e}\} and Laudina Rodr{\'i}guez and Duell, \{Eric J\} and G{\"o}ran Hallmans and Melin, \{Beatrice S\} and Jonas Manjer and Signe Borgquist and Kay-Tee Khaw and Nick Wareham and Allen, \{Naomi E\} and Tsilidis, \{Konstantinos K\} and Isabelle Romieu and Sabina Rinaldi and Paolo Vineis and Elio Riboli",

note = "{\textcopyright}2010 AACR.",

year = "2010",

doi = "10.1158/1055-9965.EPI-10-0447",

language = "English",

volume = "19",

pages = "2562--9",

journal = "Cancer Epidemiology, Biomarkers \& Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

number = "10",

}

Michaud, DS, Gallo, V, Schlehofer, B, Tjønneland, A, Olsen, A, Overvad, K, Dahm, CC, Kaaks, R, Lukanova, A, Boeing, H, Schütze, M, Trichopoulou, A, Bamia, C, Kyrozis, A, Sacerdote, C, Agnoli, C, Palli, D, Tumino, R, Mattiello, A, Bueno-de-Mesquita, HB, Ros, MM, Peeters, PHM, van Gils, CH, Lund, E, Bakken, K, Gram, IT, Barricarte, A, Navarro, C, Dorronsoro, M, Sánchez, MJ, Rodríguez, L, Duell, EJ, Hallmans, G, Melin, BS, Manjer, J, Borgquist, S, Khaw, K-T, Wareham, N, Allen, NE, Tsilidis, KK, Romieu, I, Rinaldi, S, Vineis, P & Riboli, E 2010, 'Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study', Cancer Epidemiology, Biomarkers & Prevention, vol. 19, no. 10, pp. 2562-9. https://doi.org/10.1158/1055-9965.EPI-10-0447

TY - JOUR

T1 - Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study

AU - Michaud, Dominique S

AU - Gallo, Valentina

AU - Schlehofer, Brigitte

AU - Tjønneland, Anne

AU - Olsen, Anja

AU - Overvad, Kim

AU - Dahm, Christina C

AU - Kaaks, Rudolf

AU - Lukanova, Annekatrin

AU - Boeing, Heiner

AU - Schütze, Madlen

AU - Trichopoulou, Antonia

AU - Bamia, Christina

AU - Kyrozis, Andreas

AU - Sacerdote, Carlotta

AU - Agnoli, Claudia

AU - Palli, Domenico

AU - Tumino, Rosario

AU - Mattiello, Amalia

AU - Bueno-de-Mesquita, H Bas

AU - Ros, Martine M

AU - Peeters, Petra H M

AU - van Gils, Carla H

AU - Lund, Eiliv

AU - Bakken, Kjersti

AU - Gram, Inger T

AU - Barricarte, Aurelio

AU - Navarro, Carmen

AU - Dorronsoro, Miren

AU - Sánchez, Maria José

AU - Rodríguez, Laudina

AU - Duell, Eric J

AU - Hallmans, Göran

AU - Melin, Beatrice S

AU - Manjer, Jonas

AU - Borgquist, Signe

AU - Khaw, Kay-Tee

AU - Wareham, Nick

AU - Allen, Naomi E

AU - Tsilidis, Konstantinos K

AU - Romieu, Isabelle

AU - Rinaldi, Sabina

AU - Vineis, Paolo

AU - Riboli, Elio

PY - 2010

Y1 - 2010

N2 - BACKGROUND: The etiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and the risk of glioma and meningioma among women in the European Prospective Investigation into Cancer and Nutrition (EPIC).METHODS: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma cases were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95% confidence intervals (95% CI).RESULTS: No associations were observed between glioma or meningioma risk and reproductive factors, including age at menarche, parity, age at first birth, menopausal status, and age at menopause. A higher risk of meningioma was observed among postmenopausal women who were current users of hormone replacement therapy (HR, 1.79; 95% CI, 1.18-2.71) compared with never users. Similarly, current users of oral contraceptives were at higher risk of meningioma than never users (HR, 3.61; 95% CI, 1.75-7.46).CONCLUSION: Our results do not support a role for estrogens and glioma risk. Use of exogenous hormones, especially current use, seems to increase meningioma risk. However, these findings could be due to diagnostic bias and require confirmation.IMPACT: Elucidating the role of hormones in brain tumor development has important implications and needs to be further examined using biological measurements.

AB - BACKGROUND: The etiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and the risk of glioma and meningioma among women in the European Prospective Investigation into Cancer and Nutrition (EPIC).METHODS: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma cases were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95% confidence intervals (95% CI).RESULTS: No associations were observed between glioma or meningioma risk and reproductive factors, including age at menarche, parity, age at first birth, menopausal status, and age at menopause. A higher risk of meningioma was observed among postmenopausal women who were current users of hormone replacement therapy (HR, 1.79; 95% CI, 1.18-2.71) compared with never users. Similarly, current users of oral contraceptives were at higher risk of meningioma than never users (HR, 3.61; 95% CI, 1.75-7.46).CONCLUSION: Our results do not support a role for estrogens and glioma risk. Use of exogenous hormones, especially current use, seems to increase meningioma risk. However, these findings could be due to diagnostic bias and require confirmation.IMPACT: Elucidating the role of hormones in brain tumor development has important implications and needs to be further examined using biological measurements.

KW - Brain Neoplasms/epidemiology

KW - Cohort Studies

KW - Contraceptives, Oral/administration & dosage

KW - Europe/epidemiology

KW - Female

KW - Glioma/epidemiology

KW - Hormone Replacement Therapy/adverse effects

KW - Humans

KW - Meningeal Neoplasms/epidemiology

KW - Meningioma/epidemiology

KW - Middle Aged

KW - Pregnancy

KW - Prospective Studies

KW - Reproductive History

U2 - 10.1158/1055-9965.EPI-10-0447

DO - 10.1158/1055-9965.EPI-10-0447

M3 - Article

C2 - 20802020

SN - 1055-9965

VL - 19

SP - 2562

EP - 2569

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

IS - 10

ER -

Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study

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Keywords

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