@article{fc0d7a18ee5c46fa8c608adf9b20d7fd,
title = "Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance",
abstract = "Multidrug resistance (MDR) is one of the main impediments in successful chemotherapy in cancer treatment. Overexpression of ATP-binding cassette (ABC) transporter proteins is one of the most important mechanisms of MDR. Natural products have their unique advantages in reversing MDR, among which diterpenoids have attracted great attention of the researchers around the world. This review article summarizes and discusses the research progress on diterpenoids in reversing MDR.",
keywords = "cancer, chemotherapy, diterpenoids, multidrug resistance, natural products",
author = "Deng, {Zhuo Fen} and Irina Bakunina and Hua Yu and Jaehong Han and Alexander D{\"o}mling and Ferreira, {Maria Jos{\'e} U.} and Zhang, {Jian Ye}",
note = "Funding Information: This work was supported by National Key R&D Program of China (2021YFE0202000), National Natural Science Foundation of China (U1903126), Fund of Guangdong Education Department (2021ZDZX2006), the Natural Science Foundation of Guangdong Province (2020A1515010605) and Funda??o para a Ci?ncia e a Tecnologia (FCT), Portugal (PTDC/MED-QUI/30591/2017). Funding Information: This work was supported by National Key R&D Program of China (2021YFE0202000), National Natural Science Foundation of China (U1903126), Fund of Guangdong Education Department (2021ZDZX2006), the Natural Science Foundation of Guangdong Province (2020A1515010605) and Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia (FCT), Portugal (PTDC/MED-QUI/30591/2017). Publisher Copyright: Copyright {\textcopyright} 2022 Deng, Bakunina, Yu, Han, D{\"o}mling, Ferreira and Zhang.",
year = "2022",
month = mar,
day = "28",
doi = "10.3389/fphar.2022.815603",
language = "English",
volume = "13",
journal = "Frontiers in Pharmacology",
issn = "1663-9812",
publisher = "Frontiers Media SA",
}