Abstract
A novel and versatile design of DNA-lipid conjugates is presented. The assembly of the DNA headgroups into G-quadruplex structures is essential for the formation of micelles and their stability. By hybridization with a complementary oligonucleotide the micelles were destabilized, resulting in cargo release. In combination with a hairpin DNA aptamer as complementary strand, the release is obtained selectively by the presence of ATP.
| Original language | English |
|---|---|
| Pages (from-to) | 260-263 |
| Number of pages | 4 |
| Journal | Chemical communications (Cambridge, England) |
| Volume | 54 |
| Early online date | 6-Dec-2017 |
| DOIs | |
| Publication status | Published - 11-Jan-2018 |
Keywords
- micelles
- DNA G-quadruplex
- DNA-lipid conjugates
- hybridization
- cargo release
- RELEASE
- COMPLEX
- ENERGY-TRANSFER
- NILE RED
- APTAMER
- STABILITY
- SEQUENCES
- SWITCHES