Responsive DNA G-quadruplex micelles

Liliana Cozzoli, Lorina Gjonaj, Marc C A Stuart, Bert Poolman, Gerard Roelfes

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Abstract

A novel and versatile design of DNA-lipid conjugates is presented. The assembly of the DNA headgroups into G-quadruplex structures is essential for the formation of micelles and their stability. By hybridization with a complementary oligonucleotide the micelles were destabilized, resulting in cargo release. In combination with a hairpin DNA aptamer as complementary strand, the release is obtained selectively by the presence of ATP.

Original languageEnglish
Pages (from-to)260-263
Number of pages4
JournalChemical communications (Cambridge, England)
Volume54
Early online date6-Dec-2017
DOIs
Publication statusPublished - 11-Jan-2018

Keywords

  • micelles
  • DNA G-quadruplex
  • DNA-lipid conjugates
  • hybridization
  • cargo release
  • RELEASE
  • COMPLEX
  • ENERGY-TRANSFER
  • NILE RED
  • APTAMER
  • STABILITY
  • SEQUENCES
  • SWITCHES

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