TY - JOUR
T1 - Results from the European Prospective Investigation into Cancer and Nutrition Link Vitamin B6 Catabolism and Lung Cancer Risk
AU - Zuo, Hui
AU - Ueland, Per M
AU - Midttun, Øivind
AU - Vollset, Stein E
AU - Tell, Grethe S
AU - Theofylaktopoulou, Despoina
AU - Travis, Ruth C
AU - Boutron-Ruault, Marie-Christine
AU - Fournier, Agnès
AU - Severi, Gianluca
AU - Kvaskoff, Marina
AU - Boeing, Heiner
AU - Bergmann, Manuela M
AU - Fortner, Renée T
AU - Kaaks, Rudolf
AU - Trichopoulou, Antonia
AU - Kotanidou, Anastasia
AU - Lagiou, Pagona
AU - Palli, Domenico
AU - Sieri, Sabina
AU - Panico, Salvatore
AU - Bueno-de-Mesquita, H Bas
AU - Peeters, Petra H
AU - Grankvist, Kjell
AU - Johansson, Mikael
AU - Agudo, Antonio
AU - Garcia, Jose Ramon Quiros
AU - Larranaga, Nerea
AU - Sanchez, Maria-Jose
AU - Chirlaque, Maria Dolores
AU - Ardanaz, Eva
AU - Chuang, Shu-Chun
AU - Gallo, Valentina
AU - Brennan, Paul
AU - Johansson, Mattias
AU - Ulvik, Arve
N1 - ©2017 American Association for Cancer Research.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Circulating pyridoxal-5'-phosphate (PLP) has been linked to lung cancer risk. The PAr index, defined as the ratio 4-pyridoxic acid/(pyridoxal + PLP), reflects increased vitamin B6 catabolism during inflammation. PAr has been defined as a marker of lung cancer risk in a prospective cohort study, but analysis of a larger numbers of cases are needed to deepen the significance of this study. Here, we conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC, n = 521,330), which included 892 incident lung cancer cases and 1,748 controls matched by center, gender, date of blood collection, and date of birth. The association of PAr with risk of lung cancer was evaluated by using conditional logistic regression. Study participants with elevated PAr experienced higher risk of lung cancer in a dose-response fashion, with a doubling in PAr levels associated with 52% higher odds of lung cancer after adjustment for tobacco smoking, serum cotinine levels, educational attainment, and BMI [OR, 1.52; 95% confidence interval (CI) 1.27-1.81; P < 0.001]. Additional adjustment for intake of vegetables and fruits and physical activity did not materially affect risk association. The association of PAr with lung cancer risk was similar in both genders but slightly stronger in former smokers and in participants diagnosed with squamous cell carcinoma. This study provides robust evidence that increased vitamin B6 catabolism is independently associated with a higher risk of future lung cancer.Significance: This large cohort study firmly establishes an association between an index of vitamin B6 levels with lung cancer risk. Cancer Res; 78(1); 302-8. ©2017 AACR.
AB - Circulating pyridoxal-5'-phosphate (PLP) has been linked to lung cancer risk. The PAr index, defined as the ratio 4-pyridoxic acid/(pyridoxal + PLP), reflects increased vitamin B6 catabolism during inflammation. PAr has been defined as a marker of lung cancer risk in a prospective cohort study, but analysis of a larger numbers of cases are needed to deepen the significance of this study. Here, we conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC, n = 521,330), which included 892 incident lung cancer cases and 1,748 controls matched by center, gender, date of blood collection, and date of birth. The association of PAr with risk of lung cancer was evaluated by using conditional logistic regression. Study participants with elevated PAr experienced higher risk of lung cancer in a dose-response fashion, with a doubling in PAr levels associated with 52% higher odds of lung cancer after adjustment for tobacco smoking, serum cotinine levels, educational attainment, and BMI [OR, 1.52; 95% confidence interval (CI) 1.27-1.81; P < 0.001]. Additional adjustment for intake of vegetables and fruits and physical activity did not materially affect risk association. The association of PAr with lung cancer risk was similar in both genders but slightly stronger in former smokers and in participants diagnosed with squamous cell carcinoma. This study provides robust evidence that increased vitamin B6 catabolism is independently associated with a higher risk of future lung cancer.Significance: This large cohort study firmly establishes an association between an index of vitamin B6 levels with lung cancer risk. Cancer Res; 78(1); 302-8. ©2017 AACR.
KW - Adult
KW - Aged
KW - Case-Control Studies
KW - Europe
KW - Female
KW - Humans
KW - Lung Neoplasms/etiology
KW - Male
KW - Middle Aged
KW - Prospective Studies
KW - Pyridoxal Phosphate/metabolism
KW - Pyridoxic Acid/metabolism
KW - Risk Factors
KW - Vitamin B 6/blood
UR - https://www.mendeley.com/catalogue/821ee28c-9888-367f-95e7-706dc63bd2ff/
U2 - 10.1158/0008-5472.CAN-17-1923
DO - 10.1158/0008-5472.CAN-17-1923
M3 - Article
C2 - 29070616
SN - 0008-5472
VL - 78
SP - 302
EP - 308
JO - Cancer Research
JF - Cancer Research
IS - 1
ER -