Retention of Antimicrobial Activity in Plaque and Saliva following Mouthrinse Use in vivo

M. P. T. Otten, H. J. Busscher, H. C. van der Mei, F. Abbas, C. G. van Hoogmoed*

*Corresponding author for this work

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Abstract

The aim of this study was to determine the contribution of plaque and saliva towards the prolonged activity, also called substantivity, of three antimicrobial mouthrinses (Listerine (R), Meridol (R), Crest Pro Health (R)), used in combination with a toothpaste (Prodent Coolmint (R)). Volunteers brushed for 4 weeks with a toothpaste without antimicrobial claims, while during the last 2 weeks half of the volunteers used an antimicrobial mouthrinse in addition to brushing. At the end of the experimental period, plaque and saliva samples were collected 6 h after oral hygiene, and bacterial concentrations and viabilities were determined. The contribution of plaque and saliva towards substantivity was assessed by combining plaque obtained after mechanical cleaning only with plaque and saliva obtained after additional use of an antimicrobial rinse. Subsequently, resulting viabilities of the combined plaques were determined. The viabilities of plaque samples after additional rinsing with mouthrinses were lower than of plaque obtained after mechanical cleaning only, regardless of the rinse involved. Moreover, plaque collected 6 h after rinsing with antimicrobial mouthrinses contained a surplus of antimicrobial activity. Only Listerine showed decreased vi-

Original languageEnglish
Pages (from-to)459-464
Number of pages6
JournalCARIES RESEARCH
Volume44
Issue number5
DOIs
Publication statusPublished - 2010

Keywords

  • Mouthrinses
  • Oral antimicrobials
  • Plaque
  • Substantivity
  • CHLORHEXIDINE MOUTHRINSES
  • DENTAL PLAQUE
  • GINGIVITIS
  • LISTERINE
  • EFFICACY
  • MERIDOL
  • AGENTS

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