Reticuloendothelial Fc receptor function in SLE patients. II. Associations with humoral immune response parameters in vivo and in vitro.

F. J. van der Woude; C. G. M. Kallenberg; P. C. Limburg; H. Beekhuis; W. Ouwehand; M. van der Giessen; P. J. Hoedemaeker; G. K. van der Hem; T. Hauw The

Reticuloendothelial Fc receptor function in SLE patients. II. Associations with humoral immune response parameters in vivo and in vitro.

F. J. van der Woude, C. G. M. Kallenberg, P. C. Limburg, H. Beekhuis, W. Ouwehand, M. van der Giessen, P. J. Hoedemaeker, G. K. van der Hem, T. Hauw The

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Abstract

We studied the relationship between reticuloendothelial Fc receptor function and some parameters of the humoral immune response in vivo and in vitro in 18 SLE patients. Fc receptor-mediated immune clearance correlated remarkably well with (a) a decrease of antigen specific IgG after immunization with a primary test antigen (alpha-Helix pomatia haemocyanin) (P less than 0.01) and (b) the spontaneous IgG release in vitro of B cells obtained from peripheral blood (P less than 0.01). These two parameters were significantly interrelated. Reticuloendothelial Fc receptor function was not related to serum IgG levels. The study provides evidence for an association between polyclonal B cell activation and Fc receptor-mediated immune clearance in SLE patients. The possible nature of this association is discussed.

Original language	English
Pages (from-to)	481-486
Number of pages	6
Journal	Clinical and Experimental Immunology
Volume	55
Issue number	3
Publication status	Published - Mar-1984

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Reticuloendothelial Fc receptor function in SLE patients. II.
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van der Woude, F. J., Kallenberg, C. G. M., Limburg, P. C., Beekhuis, H., Ouwehand, W., van der Giessen, M., Hoedemaeker, P. J., van der Hem, G. K., & The, T. H. (1984). Reticuloendothelial Fc receptor function in SLE patients. II. Associations with humoral immune response parameters in vivo and in vitro. Clinical and Experimental Immunology, 55(3), 481-486. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1535934/

van der Woude, F. J. ; Kallenberg, C. G. M. ; Limburg, P. C. ; Beekhuis, H. ; Ouwehand, W. ; van der Giessen, M. ; Hoedemaeker, P. J. ; van der Hem, G. K. ; The, T. Hauw. / Reticuloendothelial Fc receptor function in SLE patients. II. Associations with humoral immune response parameters in vivo and in vitro. In: Clinical and Experimental Immunology. 1984 ; Vol. 55, No. 3. pp. 481-486.

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abstract = "We studied the relationship between reticuloendothelial Fc receptor function and some parameters of the humoral immune response in vivo and in vitro in 18 SLE patients. Fc receptor-mediated immune clearance correlated remarkably well with (a) a decrease of antigen specific IgG after immunization with a primary test antigen (alpha-Helix pomatia haemocyanin) (P less than 0.01) and (b) the spontaneous IgG release in vitro of B cells obtained from peripheral blood (P less than 0.01). These two parameters were significantly interrelated. Reticuloendothelial Fc receptor function was not related to serum IgG levels. The study provides evidence for an association between polyclonal B cell activation and Fc receptor-mediated immune clearance in SLE patients. The possible nature of this association is discussed.",

author = "{van der Woude}, {F. J.} and Kallenberg, {C. G. M.} and Limburg, {P. C.} and H. Beekhuis and W. Ouwehand and {van der Giessen}, M. and Hoedemaeker, {P. J.} and {van der Hem}, {G. K.} and The, {T. Hauw}",

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van der Woude, FJ, Kallenberg, CGM, Limburg, PC, Beekhuis, H, Ouwehand, W, van der Giessen, M, Hoedemaeker, PJ, van der Hem, GK & The, TH 1984, 'Reticuloendothelial Fc receptor function in SLE patients. II. Associations with humoral immune response parameters in vivo and in vitro.', Clinical and Experimental Immunology, vol. 55, no. 3, pp. 481-486. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1535934/>

Reticuloendothelial Fc receptor function in SLE patients. II. Associations with humoral immune response parameters in vivo and in vitro. / van der Woude, F. J.; Kallenberg, C. G. M.; Limburg, P. C.; Beekhuis, H.; Ouwehand, W.; van der Giessen, M.; Hoedemaeker, P. J.; van der Hem, G. K.; The, T. Hauw.

In: Clinical and Experimental Immunology, Vol. 55, No. 3, 03.1984, p. 481-486.

Research output: Contribution to journal › Article › Academic › peer-review

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AB - We studied the relationship between reticuloendothelial Fc receptor function and some parameters of the humoral immune response in vivo and in vitro in 18 SLE patients. Fc receptor-mediated immune clearance correlated remarkably well with (a) a decrease of antigen specific IgG after immunization with a primary test antigen (alpha-Helix pomatia haemocyanin) (P less than 0.01) and (b) the spontaneous IgG release in vitro of B cells obtained from peripheral blood (P less than 0.01). These two parameters were significantly interrelated. Reticuloendothelial Fc receptor function was not related to serum IgG levels. The study provides evidence for an association between polyclonal B cell activation and Fc receptor-mediated immune clearance in SLE patients. The possible nature of this association is discussed.

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