Retinoic Acid as Antileukemic Therapy in a Patient With Acute Promyelocytic Leukemia and Aspergillus Pneumonia

S. Daenen; E. Vellenga; O. A. van Dobbenburgh; M. R. Halie

Retinoic Acid as Antileukemic Therapy in a Patient With Acute Promyelocytic Leukemia and Aspergillus Pneumonia

S. Daenen^*
, E. Vellenga
, O. A. van Dobbenburgh
, M. R. Halie

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

A patient with acute promyelocytic leukemia (APL) and laboratory evidence of fibrinolysis who could not be treated with aggressive cytostatic regimens because of Aspergillus pneumonia was treated with cis-retinoic acid (RA), a substance that can induce differentiation and maturation of APL cells. After seven weeks of daily oral treatment, he went into complete remission, and signs of coagulopathy disappeared. Meanwhile, the Aspergillus pneumonia could be treated adequately. Based on the experience in this single patient, RA deserves further evaluation in the treatment of APL

Original language	English
Pages (from-to)	559-561
Number of pages	3
Journal	Blood
Volume	67
Issue number	2
Publication status	Published - Feb-1986

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@article{dd6f1a5528b2421f9cccbfd38a2312c3,

title = "Retinoic Acid as Antileukemic Therapy in a Patient With Acute Promyelocytic Leukemia and Aspergillus Pneumonia",

abstract = "A patient with acute promyelocytic leukemia (APL) and laboratory evidence of fibrinolysis who could not be treated with aggressive cytostatic regimens because of Aspergillus pneumonia was treated with cis-retinoic acid (RA), a substance that can induce differentiation and maturation of APL cells. After seven weeks of daily oral treatment, he went into complete remission, and signs of coagulopathy disappeared. Meanwhile, the Aspergillus pneumonia could be treated adequately. Based on the experience in this single patient, RA deserves further evaluation in the treatment of APL",

author = "S. Daenen and E. Vellenga and \{van Dobbenburgh\}, \{O. A.\} and Halie, \{M. R.\}",

year = "1986",

month = feb,

language = "English",

volume = "67",

pages = "559--561",

journal = "Blood",

issn = "0006-4971",

publisher = "AMER SOC HEMATOLOGY",

number = "2",

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TY - JOUR

T1 - Retinoic Acid as Antileukemic Therapy in a Patient With Acute Promyelocytic Leukemia and Aspergillus Pneumonia

AU - Daenen, S.

AU - Vellenga, E.

AU - van Dobbenburgh, O. A.

AU - Halie, M. R.

PY - 1986/2

Y1 - 1986/2

N2 - A patient with acute promyelocytic leukemia (APL) and laboratory evidence of fibrinolysis who could not be treated with aggressive cytostatic regimens because of Aspergillus pneumonia was treated with cis-retinoic acid (RA), a substance that can induce differentiation and maturation of APL cells. After seven weeks of daily oral treatment, he went into complete remission, and signs of coagulopathy disappeared. Meanwhile, the Aspergillus pneumonia could be treated adequately. Based on the experience in this single patient, RA deserves further evaluation in the treatment of APL

AB - A patient with acute promyelocytic leukemia (APL) and laboratory evidence of fibrinolysis who could not be treated with aggressive cytostatic regimens because of Aspergillus pneumonia was treated with cis-retinoic acid (RA), a substance that can induce differentiation and maturation of APL cells. After seven weeks of daily oral treatment, he went into complete remission, and signs of coagulopathy disappeared. Meanwhile, the Aspergillus pneumonia could be treated adequately. Based on the experience in this single patient, RA deserves further evaluation in the treatment of APL

M3 - Article

SN - 0006-4971

VL - 67

SP - 559

EP - 561

JO - Blood

JF - Blood

IS - 2

ER -

Retinoic Acid as Antileukemic Therapy in a Patient With Acute Promyelocytic Leukemia and Aspergillus Pneumonia

Abstract

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