Retrospective Study of the Association Between Platelet-to-Lymphocyte Ratio in Patients with Acute Coronary Syndrome on Admission to a Rural Referral Center in East Java, Indonesia, and the Incidence of New Symptomatic Heart Failure at 6 Months

Ryan Enast Intan; Firas Farisi Alkaff; Yudi Her Oktaviono; Ricardo Adrian Nugraha; Tan Nicko Octora; Michael Jonatan; Dimas Rio Balti; Fani Suslina Hasibuan; Basuni Radi; Anwar Santoso

doi:10.12659/MSM.935002

Retrospective Study of the Association Between Platelet-to-Lymphocyte Ratio in Patients with Acute Coronary Syndrome on Admission to a Rural Referral Center in East Java, Indonesia, and the Incidence of New Symptomatic Heart Failure at 6 Months

Ryan Enast Intan^*, Firas Farisi Alkaff, Yudi Her Oktaviono, Ricardo Adrian Nugraha, Tan Nicko Octora, Michael Jonatan, Dimas Rio Balti, Fani Suslina Hasibuan, Basuni Radi, Anwar Santoso

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Y Background: This was a retrospective study conducted at a rural referral center in East Java, Indonesia, to evaluate the association between the platelet-to-lymphocyte ratio (PLR) on hospital admission and the incidence of new symptomatic heart failure (HF) within 6 months in patients with acute coronary syndrome (ACS).

Material/Methods: The study population consisted of all ACS patients who were hospitalized between 1 January and 31 December 2018 at a non-percutaneous coronary intervention-capable secondary referral hospital and came for a routine follow-up until 6 months afterwards. The diagnosis of new symptomatic HF was based on International Classification of Diseases 10th revision code I50.9.

Results: From 126 hospitalized patients, 92 patients were included in the analysis. The incidence rate of new symptomatic HF at 6 months was 70.65%. High PLR upon initial admission was significantly associated with new symptomatic HF incidence (odds ratio=1.70, P

Conclusions: In a rural center in Indonesia, the PLR was independently correlated with the onset of new symptomatic HF in patients with ACS 6 months after hospital admission. The PLR may be a supplementary biomarker for clinical outcomes in patients with ACS for use in resource-limited regions.

Original language	English
Article number	935002
Number of pages	9
Journal	Medical Science Monitor
Volume	28
DOIs	https://doi.org/10.12659/MSM.935002
Publication status	Published - 2-Mar-2022

Keywords

Acute Coronary Syndrome
Biomarkers
Heart Failure
ADVERSE CARDIOVASCULAR EVENTS
ST-SEGMENT ELEVATION
MYOCARDIAL-INFARCTION
ARTERY-DISEASE
INFLAMMATION
PROGNOSIS
RISK
DYSFUNCTION
SEVERITY
MARKER

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Intan, R. E., Alkaff, F. F., Oktaviono, Y. H., Nugraha, R. A., Octora, T. N., Jonatan, M., Balti, D. R., Hasibuan, F. S., Radi, B., & Santoso, A. (2022). Retrospective Study of the Association Between Platelet-to-Lymphocyte Ratio in Patients with Acute Coronary Syndrome on Admission to a Rural Referral Center in East Java, Indonesia, and the Incidence of New Symptomatic Heart Failure at 6 Months. Medical Science Monitor, 28, Article 935002. https://doi.org/10.12659/MSM.935002

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title = "Retrospective Study of the Association Between Platelet-to-Lymphocyte Ratio in Patients with Acute Coronary Syndrome on Admission to a Rural Referral Center in East Java, Indonesia, and the Incidence of New Symptomatic Heart Failure at 6 Months",

abstract = "Y Background: This was a retrospective study conducted at a rural referral center in East Java, Indonesia, to evaluate the association between the platelet-to-lymphocyte ratio (PLR) on hospital admission and the incidence of new symptomatic heart failure (HF) within 6 months in patients with acute coronary syndrome (ACS).Material/Methods: The study population consisted of all ACS patients who were hospitalized between 1 January and 31 December 2018 at a non-percutaneous coronary intervention-capable secondary referral hospital and came for a routine follow-up until 6 months afterwards. The diagnosis of new symptomatic HF was based on International Classification of Diseases 10th revision code I50.9.Results: From 126 hospitalized patients, 92 patients were included in the analysis. The incidence rate of new symptomatic HF at 6 months was 70.65%. High PLR upon initial admission was significantly associated with new symptomatic HF incidence (odds ratio=1.70, PConclusions: In a rural center in Indonesia, the PLR was independently correlated with the onset of new symptomatic HF in patients with ACS 6 months after hospital admission. The PLR may be a supplementary biomarker for clinical outcomes in patients with ACS for use in resource-limited regions.",

keywords = "Acute Coronary Syndrome, Biomarkers, Heart Failure, ADVERSE CARDIOVASCULAR EVENTS, ST-SEGMENT ELEVATION, MYOCARDIAL-INFARCTION, ARTERY-DISEASE, INFLAMMATION, PROGNOSIS, RISK, DYSFUNCTION, SEVERITY, MARKER",

author = "Intan, {Ryan Enast} and Alkaff, {Firas Farisi} and Oktaviono, {Yudi Her} and Nugraha, {Ricardo Adrian} and Octora, {Tan Nicko} and Michael Jonatan and Balti, {Dimas Rio} and Hasibuan, {Fani Suslina} and Basuni Radi and Anwar Santoso",

year = "2022",

month = mar,

day = "2",

doi = "10.12659/MSM.935002",

language = "English",

volume = "28",

journal = "Medical Science Monitor",

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Intan, RE, Alkaff, FF, Oktaviono, YH, Nugraha, RA, Octora, TN, Jonatan, M, Balti, DR, Hasibuan, FS, Radi, B & Santoso, A 2022, 'Retrospective Study of the Association Between Platelet-to-Lymphocyte Ratio in Patients with Acute Coronary Syndrome on Admission to a Rural Referral Center in East Java, Indonesia, and the Incidence of New Symptomatic Heart Failure at 6 Months', Medical Science Monitor, vol. 28, 935002. https://doi.org/10.12659/MSM.935002

Retrospective Study of the Association Between Platelet-to-Lymphocyte Ratio in Patients with Acute Coronary Syndrome on Admission to a Rural Referral Center in East Java, Indonesia, and the Incidence of New Symptomatic Heart Failure at 6 Months. / Intan, Ryan Enast; Alkaff, Firas Farisi; Oktaviono, Yudi Her et al.
In: Medical Science Monitor, Vol. 28, 935002, 02.03.2022.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Retrospective Study of the Association Between Platelet-to-Lymphocyte Ratio in Patients with Acute Coronary Syndrome on Admission to a Rural Referral Center in East Java, Indonesia, and the Incidence of New Symptomatic Heart Failure at 6 Months

AU - Intan, Ryan Enast

AU - Alkaff, Firas Farisi

AU - Oktaviono, Yudi Her

AU - Nugraha, Ricardo Adrian

AU - Octora, Tan Nicko

AU - Jonatan, Michael

AU - Balti, Dimas Rio

AU - Hasibuan, Fani Suslina

AU - Radi, Basuni

AU - Santoso, Anwar

PY - 2022/3/2

Y1 - 2022/3/2

N2 - Y Background: This was a retrospective study conducted at a rural referral center in East Java, Indonesia, to evaluate the association between the platelet-to-lymphocyte ratio (PLR) on hospital admission and the incidence of new symptomatic heart failure (HF) within 6 months in patients with acute coronary syndrome (ACS).Material/Methods: The study population consisted of all ACS patients who were hospitalized between 1 January and 31 December 2018 at a non-percutaneous coronary intervention-capable secondary referral hospital and came for a routine follow-up until 6 months afterwards. The diagnosis of new symptomatic HF was based on International Classification of Diseases 10th revision code I50.9.Results: From 126 hospitalized patients, 92 patients were included in the analysis. The incidence rate of new symptomatic HF at 6 months was 70.65%. High PLR upon initial admission was significantly associated with new symptomatic HF incidence (odds ratio=1.70, PConclusions: In a rural center in Indonesia, the PLR was independently correlated with the onset of new symptomatic HF in patients with ACS 6 months after hospital admission. The PLR may be a supplementary biomarker for clinical outcomes in patients with ACS for use in resource-limited regions.

AB - Y Background: This was a retrospective study conducted at a rural referral center in East Java, Indonesia, to evaluate the association between the platelet-to-lymphocyte ratio (PLR) on hospital admission and the incidence of new symptomatic heart failure (HF) within 6 months in patients with acute coronary syndrome (ACS).Material/Methods: The study population consisted of all ACS patients who were hospitalized between 1 January and 31 December 2018 at a non-percutaneous coronary intervention-capable secondary referral hospital and came for a routine follow-up until 6 months afterwards. The diagnosis of new symptomatic HF was based on International Classification of Diseases 10th revision code I50.9.Results: From 126 hospitalized patients, 92 patients were included in the analysis. The incidence rate of new symptomatic HF at 6 months was 70.65%. High PLR upon initial admission was significantly associated with new symptomatic HF incidence (odds ratio=1.70, PConclusions: In a rural center in Indonesia, the PLR was independently correlated with the onset of new symptomatic HF in patients with ACS 6 months after hospital admission. The PLR may be a supplementary biomarker for clinical outcomes in patients with ACS for use in resource-limited regions.

KW - Acute Coronary Syndrome

KW - Biomarkers

KW - Heart Failure

KW - ADVERSE CARDIOVASCULAR EVENTS

KW - ST-SEGMENT ELEVATION

KW - MYOCARDIAL-INFARCTION

KW - ARTERY-DISEASE

KW - INFLAMMATION

KW - PROGNOSIS

KW - RISK

KW - DYSFUNCTION

KW - SEVERITY

KW - MARKER

U2 - 10.12659/MSM.935002

DO - 10.12659/MSM.935002

M3 - Article

SN - 1234-1010

VL - 28

JO - Medical Science Monitor

JF - Medical Science Monitor

M1 - 935002

ER -

Intan RE, Alkaff FF, Oktaviono YH, Nugraha RA, Octora TN, Jonatan M et al. Retrospective Study of the Association Between Platelet-to-Lymphocyte Ratio in Patients with Acute Coronary Syndrome on Admission to a Rural Referral Center in East Java, Indonesia, and the Incidence of New Symptomatic Heart Failure at 6 Months. Medical Science Monitor. 2022 Mar 2;28:935002. doi: 10.12659/MSM.935002