TY - PAT
T1 - Reversible photo-controlled frac nanopores, modified frac monomers, methods for preparing the same, and uses thereof
AU - Maglia, Giovanni
AU - Mutter, Natalie Lisa
AU - Volaric, Jana
AU - Feringa, Bernard Lucas
AU - Szymanski, Wiktor Czeslaw
PY - 2021/2/3
Y1 - 2021/2/3
N2 - The invention relates to the fields of photopharmacology and photo-controlled analyte sensing. More in particular, it relates to a pore forming toxin Fragaceatoxin C (FraC) from Actina fragacea that can be reversibly controlled by using light as external trigger. Provided is a modified FraC monomer capable of forming a photo-controlled FraC nanopore, the FraC monomer comprising a photoswitchable moiety, e.g. an azobenzene-based photoswitch, covalently attached to one or more of the positions K77, W112, E134, Y138, and S166.
AB - The invention relates to the fields of photopharmacology and photo-controlled analyte sensing. More in particular, it relates to a pore forming toxin Fragaceatoxin C (FraC) from Actina fragacea that can be reversibly controlled by using light as external trigger. Provided is a modified FraC monomer capable of forming a photo-controlled FraC nanopore, the FraC monomer comprising a photoswitchable moiety, e.g. an azobenzene-based photoswitch, covalently attached to one or more of the positions K77, W112, E134, Y138, and S166.
M3 - Patent
M1 - EP3771687
Y2 - 2019/07/30
ER -