Review - Late toxicity of abdominal and pelvic radiotherapy for childhood cancer

Arno C Hessels, Johannes A Langendijk, Agata Gawryszuk, Mart A A M Heesters, Nathalie L M van der Salm, Wim J E Tissing, Hiske L van der Weide, John H Maduro*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

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Abstract

As survival improves in childhood cancer, prevention of late treatment-related toxicity in survivors becomes increasingly relevant. Radiotherapy is an important contributor to late toxicity. Therefore, minimizing radiation exposure to normal tissues is an important step towards improving the long-term therapeutic window of childhood cancer treatment. Since children are growing and developing, they are particularly vulnerable to radiation exposure. This makes the 'as low as reasonably achievable (ALARA)' principle even more important. In order to guide and achieve clinically meaningful dose reductions through advanced and emerging radiation techniques, it is important to investigate age-dependent relationships between radiation exposure to healthy tissues and late radiation-induced toxicity. In this review, we provide an overview of literature on the association between radiotherapy dose and late toxicity after abdominal and pelvic irradiation in childhood cancer. With this information, we aim to aid in decision-making regarding radiotherapy for childhood cancer. (c) 2022 The Author(s). Published by Elsevier B.V. Radiotherapy and Oncology 170 (2022) 27-36 This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Original languageEnglish
Pages (from-to)27-36
Number of pages10
JournalRadiotherapy and Oncology
Volume170
DOIs
Publication statusPublished - May-2022

Keywords

  • Adolescent
  • Cancer survivors
  • Child
  • Long term adverse effects
  • Radiotherapy
  • Review
  • LONG-TERM SURVIVORS
  • YOUNG-ADULT CANCER
  • BONE-MARROW-TRANSPLANTATION
  • PREMATURE OVARIAN INSUFFICIENCY
  • GUIDELINE HARMONIZATION GROUP
  • RISK-FACTORS
  • DIABETES-MELLITUS
  • FEMALE SURVIVORS
  • FERTILITY PRESERVATION
  • PEDIATRIC CANCER

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