Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia

M P M Boks, T Rietkerk, M H van de Beek, I E Sommer, T J de Koning, R S Kahn

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We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia. The gene product of G72 is an activator of DAAO (D-amino acid oxidase), which is the only enzyme oxidising D-serine. D-serine is an important co-agonist for the NMDA glutamate receptor and plays a role in neuronal migration and cell death. Studies of D-serine revealed lower serum levels in schizophrenia patients as compared to healthy controls. Furthermore, administration of D-serine as add-on medication reduced the symptoms of schizophrenia. The underlying mechanism of the involvement of G72 and DAAO in schizophrenia is probably based on decreased levels of D-serine and decreased NMDA receptor functioning in patients. The involvement of this gene is therefore indirect support for the glutamate dysfunction hypothesis in schizophrenia.

Original languageEnglish
Pages (from-to)567-72
Number of pages6
JournalEuropean Neuropsychopharmacology
Issue number9
Publication statusPublished - Sep-2007
Externally publishedYes


  • Carrier Proteins
  • D-Amino-Acid Oxidase
  • Genetic Predisposition to Disease
  • Glutamic Acid
  • Humans
  • Models, Biological
  • Schizophrenia
  • Synaptic Transmission
  • Journal Article
  • Review

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