Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia

M P M Boks; T Rietkerk; M H van de Beek; I E Sommer; T J de Koning; R S Kahn

doi:10.1016/j.euroneuro.2006.12.003

Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia

M P M Boks, T Rietkerk, M H van de Beek, I E Sommer, T J de Koning, R S Kahn

Research output: Contribution to journal › Review article › peer-review

71 Citations (Scopus)

Abstract

We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia. The gene product of G72 is an activator of DAAO (D-amino acid oxidase), which is the only enzyme oxidising D-serine. D-serine is an important co-agonist for the NMDA glutamate receptor and plays a role in neuronal migration and cell death. Studies of D-serine revealed lower serum levels in schizophrenia patients as compared to healthy controls. Furthermore, administration of D-serine as add-on medication reduced the symptoms of schizophrenia. The underlying mechanism of the involvement of G72 and DAAO in schizophrenia is probably based on decreased levels of D-serine and decreased NMDA receptor functioning in patients. The involvement of this gene is therefore indirect support for the glutamate dysfunction hypothesis in schizophrenia.

Original language	English
Pages (from-to)	567-72
Number of pages	6
Journal	European Neuropsychopharmacology
Volume	17
Issue number	9
DOIs	https://doi.org/10.1016/j.euroneuro.2006.12.003
Publication status	Published - Sep-2007
Externally published	Yes

Keywords

Carrier Proteins
D-Amino-Acid Oxidase
Genetic Predisposition to Disease
Glutamic Acid
Humans
Models, Biological
Schizophrenia
Synaptic Transmission
Journal Article
Review

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title = "Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia",

abstract = "We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia. The gene product of G72 is an activator of DAAO (D-amino acid oxidase), which is the only enzyme oxidising D-serine. D-serine is an important co-agonist for the NMDA glutamate receptor and plays a role in neuronal migration and cell death. Studies of D-serine revealed lower serum levels in schizophrenia patients as compared to healthy controls. Furthermore, administration of D-serine as add-on medication reduced the symptoms of schizophrenia. The underlying mechanism of the involvement of G72 and DAAO in schizophrenia is probably based on decreased levels of D-serine and decreased NMDA receptor functioning in patients. The involvement of this gene is therefore indirect support for the glutamate dysfunction hypothesis in schizophrenia.",

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author = "Boks, {M P M} and T Rietkerk and {van de Beek}, {M H} and Sommer, {I E} and {de Koning}, {T J} and Kahn, {R S}",

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T1 - Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia

AU - Boks, M P M

AU - Rietkerk, T

AU - van de Beek, M H

AU - Sommer, I E

AU - de Koning, T J

AU - Kahn, R S

N1 - 2007 Elsevier B.V and ECNP

PY - 2007/9

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N2 - We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia. The gene product of G72 is an activator of DAAO (D-amino acid oxidase), which is the only enzyme oxidising D-serine. D-serine is an important co-agonist for the NMDA glutamate receptor and plays a role in neuronal migration and cell death. Studies of D-serine revealed lower serum levels in schizophrenia patients as compared to healthy controls. Furthermore, administration of D-serine as add-on medication reduced the symptoms of schizophrenia. The underlying mechanism of the involvement of G72 and DAAO in schizophrenia is probably based on decreased levels of D-serine and decreased NMDA receptor functioning in patients. The involvement of this gene is therefore indirect support for the glutamate dysfunction hypothesis in schizophrenia.

AB - We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia. The gene product of G72 is an activator of DAAO (D-amino acid oxidase), which is the only enzyme oxidising D-serine. D-serine is an important co-agonist for the NMDA glutamate receptor and plays a role in neuronal migration and cell death. Studies of D-serine revealed lower serum levels in schizophrenia patients as compared to healthy controls. Furthermore, administration of D-serine as add-on medication reduced the symptoms of schizophrenia. The underlying mechanism of the involvement of G72 and DAAO in schizophrenia is probably based on decreased levels of D-serine and decreased NMDA receptor functioning in patients. The involvement of this gene is therefore indirect support for the glutamate dysfunction hypothesis in schizophrenia.

KW - Carrier Proteins

KW - D-Amino-Acid Oxidase

KW - Genetic Predisposition to Disease

KW - Glutamic Acid

KW - Humans

KW - Models, Biological

KW - Schizophrenia

KW - Synaptic Transmission

KW - Journal Article

KW - Review

U2 - 10.1016/j.euroneuro.2006.12.003

DO - 10.1016/j.euroneuro.2006.12.003

M3 - Review article

C2 - 17250995

VL - 17

SP - 567

EP - 572

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

SN - 0924-977X

IS - 9

ER -