Revisiting matrix metalloproteinase 12: its role in pathophysiology of asthma and related pulmonary diseases

Khalid Abd-Elaziz*, Milos Jesenak, Martina Vasakova, Zuzana Diamant

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    1 Citation (Scopus)

    Abstract

    Purpose of review Matrix metalloproteinases (MMPs) are a family of over 20 zinc-dependent proteases with different biological and pathological activities, and many have been implicated in several diseases. Although nonselective MMP inhibitors are known to induce serious side-effects, targeting individual MMPs may offer a safer therapeutic potential for several diseases. Hence, we provide a concise overview on MMP-12, given its association with pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, and other progressive pulmonary fibrosis (PPF), which may also occur in coronavirus disease 2019. Recent findings In asthma, COPD, and PPF, increased MMP-12 levels have been associated with inflammation and/or structural changes within the lungs and negatively correlated with functional parameters. Increased pulmonary MMP-12 levels and MMP-12 gene expression have been related to disease severity in asthma and COPD. Targeting MMP-12 showed potential in animal models of pulmonary diseases but human data are still very scarce. Although there may be a potential role of MMP-12 in asthma, COPD and PPF, several pathophysiological aspects await elucidation. Targeting MMP-12 may provide further insights into MMP-12 related mechanisms and how this translates into clinical outcomes; this warrants further research.

    Original languageEnglish
    Pages (from-to)54-60
    Number of pages7
    JournalCurrent Opinion in Pulmonary Medicine
    Volume27
    Issue number1
    DOIs
    Publication statusPublished - Jan-2021

    Keywords

    • asthma
    • chronic obstructive pulmonary disease
    • coronavirus disease 2019
    • matrix metalloproteinase 12
    • matrix metalloproteinase-12 inhibitor
    • pulmonary fibrosis

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