Rheumatoid arthritis and periodontitis; a possible link via citrullination

M J de Smit; Elisabeth Tonckens-Brouwer; A Vissink; A J van Winkelhoff

doi:10.1016/j.anaerobe.2011.03.019

Rheumatoid arthritis and periodontitis; a possible link via citrullination

M J de Smit^*, Elisabeth Tonckens-Brouwer, A Vissink, A J van Winkelhoff

^*Corresponding author for this work

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Abstract

Rheumatoid Arthritis (RA) and chronic and aggressive periodontitis are chronic inflammatory disorders characterized by deregulation of the host inflammatory response. Increased secretion of pro-inflammatory mediators results in soft and hard tissue destruction of the synovium and periodontium respectively. Both diseases share risk factors and have pathological pathways in common, resulting in loss of function and disability as a final clinical outcome. This article discusses possible interactions, particularly related to the periodontal pathogen Porphyromonas gingivalis, which could explain the observed association between these two prevalent diseases.

Original language	English
Pages (from-to)	196-200
Number of pages	5
Journal	Anaerobe
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.anaerobe.2011.03.019
Publication status	Published - Aug-2011

Keywords

Rheumatoid arthritis
Periodontitis
Porphyromonas gingivalis
GENE-ENVIRONMENT INTERACTIONS
PORPHYROMONAS-GINGIVALIS
RISK-FACTORS
PEPTIDYLARGININE DEIMINASE
BACTEROIDES-FORSYTHUS
ANTIBODY-RESPONSES
CIGARETTE-SMOKING
SYNOVIAL-FLUID
ALPHA-ENOLASE
TOOTH LOSS

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Rheumatoid arthritis and periodontitisFinal publisher's version, 247 KBLicence: Taverne

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@article{e16573ca1d53460cade5f0d2005c70fd,

title = "Rheumatoid arthritis and periodontitis; a possible link via citrullination",

abstract = "Rheumatoid Arthritis (RA) and chronic and aggressive periodontitis are chronic inflammatory disorders characterized by deregulation of the host inflammatory response. Increased secretion of pro-inflammatory mediators results in soft and hard tissue destruction of the synovium and periodontium respectively. Both diseases share risk factors and have pathological pathways in common, resulting in loss of function and disability as a final clinical outcome. This article discusses possible interactions, particularly related to the periodontal pathogen Porphyromonas gingivalis, which could explain the observed association between these two prevalent diseases.",

keywords = "Rheumatoid arthritis, Periodontitis, Porphyromonas gingivalis, GENE-ENVIRONMENT INTERACTIONS, PORPHYROMONAS-GINGIVALIS, RISK-FACTORS, PEPTIDYLARGININE DEIMINASE, BACTEROIDES-FORSYTHUS, ANTIBODY-RESPONSES, CIGARETTE-SMOKING, SYNOVIAL-FLUID, ALPHA-ENOLASE, TOOTH LOSS",

author = "{de Smit}, {M J} and Elisabeth Tonckens-Brouwer and A Vissink and {van Winkelhoff}, {A J}",

year = "2011",

month = aug,

doi = "10.1016/j.anaerobe.2011.03.019",

language = "English",

volume = "17",

pages = "196--200",

journal = "Anaerobe",

issn = "1075-9964",

publisher = "ELSEVIER SCI LTD",

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TY - JOUR

T1 - Rheumatoid arthritis and periodontitis; a possible link via citrullination

AU - de Smit, M J

AU - Tonckens-Brouwer, Elisabeth

AU - Vissink, A

AU - van Winkelhoff, A J

PY - 2011/8

Y1 - 2011/8

N2 - Rheumatoid Arthritis (RA) and chronic and aggressive periodontitis are chronic inflammatory disorders characterized by deregulation of the host inflammatory response. Increased secretion of pro-inflammatory mediators results in soft and hard tissue destruction of the synovium and periodontium respectively. Both diseases share risk factors and have pathological pathways in common, resulting in loss of function and disability as a final clinical outcome. This article discusses possible interactions, particularly related to the periodontal pathogen Porphyromonas gingivalis, which could explain the observed association between these two prevalent diseases.

AB - Rheumatoid Arthritis (RA) and chronic and aggressive periodontitis are chronic inflammatory disorders characterized by deregulation of the host inflammatory response. Increased secretion of pro-inflammatory mediators results in soft and hard tissue destruction of the synovium and periodontium respectively. Both diseases share risk factors and have pathological pathways in common, resulting in loss of function and disability as a final clinical outcome. This article discusses possible interactions, particularly related to the periodontal pathogen Porphyromonas gingivalis, which could explain the observed association between these two prevalent diseases.

KW - Rheumatoid arthritis

KW - Periodontitis

KW - Porphyromonas gingivalis

KW - GENE-ENVIRONMENT INTERACTIONS

KW - PORPHYROMONAS-GINGIVALIS

KW - RISK-FACTORS

KW - PEPTIDYLARGININE DEIMINASE

KW - BACTEROIDES-FORSYTHUS

KW - ANTIBODY-RESPONSES

KW - CIGARETTE-SMOKING

KW - SYNOVIAL-FLUID

KW - ALPHA-ENOLASE

KW - TOOTH LOSS

U2 - 10.1016/j.anaerobe.2011.03.019

DO - 10.1016/j.anaerobe.2011.03.019

M3 - Article

C2 - 21515392

SN - 1075-9964

VL - 17

SP - 196

EP - 200

JO - Anaerobe

JF - Anaerobe

IS - 4

ER -

Rheumatoid arthritis and periodontitis; a possible link via citrullination

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Keywords

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