Rheumatoid arthritis and periodontitis; a possible link via citrullination

Research output: Contribution to journalArticleAcademicpeer-review

38 Citations (Scopus)
546 Downloads (Pure)

Abstract

Rheumatoid Arthritis (RA) and chronic and aggressive periodontitis are chronic inflammatory disorders characterized by deregulation of the host inflammatory response. Increased secretion of pro-inflammatory mediators results in soft and hard tissue destruction of the synovium and periodontium respectively. Both diseases share risk factors and have pathological pathways in common, resulting in loss of function and disability as a final clinical outcome. This article discusses possible interactions, particularly related to the periodontal pathogen Porphyromonas gingivalis, which could explain the observed association between these two prevalent diseases.

Original languageEnglish
Pages (from-to)196-200
Number of pages5
JournalAnaerobe
Volume17
Issue number4
DOIs
Publication statusPublished - Aug-2011

Keywords

  • Rheumatoid arthritis
  • Periodontitis
  • Porphyromonas gingivalis
  • GENE-ENVIRONMENT INTERACTIONS
  • PORPHYROMONAS-GINGIVALIS
  • RISK-FACTORS
  • PEPTIDYLARGININE DEIMINASE
  • BACTEROIDES-FORSYTHUS
  • ANTIBODY-RESPONSES
  • CIGARETTE-SMOKING
  • SYNOVIAL-FLUID
  • ALPHA-ENOLASE
  • TOOTH LOSS

Fingerprint

Dive into the research topics of 'Rheumatoid arthritis and periodontitis; a possible link via citrullination'. Together they form a unique fingerprint.

Cite this