TY - JOUR
T1 - Rhinoviruses in infancy and risk of immunoglobulin E sensitization
AU - DIABIMMUNE Study Grp
AU - Korhonen, Laura
AU - Oikarinen, Sami
AU - Lehtonen, Jussi
AU - Mustonen, Neea
AU - Tyni, Iiris
AU - Niemela, Onni
AU - Honkanen, Hanna
AU - Huhtala, Heini
AU - Ilonen, Jorma
AU - Hamalainen, Anu-Maaria
AU - Peet, Aleksandr
AU - Tillmann, Vallo
AU - Siljander, Heli
AU - Knip, Mikael
AU - Lonnrot, Maria
AU - Hyoty, Heikki
AU - Harkonen, Taina
AU - Ryhanen, Samppa
AU - Siljander, Heli
AU - Koski, Katriina
AU - Koski, Matti
AU - Ormisson, Anne
AU - Ulich, Valentina
AU - Kuzmicheva, Elena
AU - Mokurov, Sergei
AU - Markova, Svetlana
AU - Pylova, Svetlana
AU - Isakova, Marina
AU - Shakurova, Elena
AU - Petrov, Vladimir
AU - Dorshakova, Natalya V.
AU - Karapetyan, Tatyana
AU - Varlamova, Tatyana
AU - Kiviniemi, Minna
AU - Alnek, Kristi
AU - Janson, Helis
AU - Uibo, Raivo
AU - Salum, Tiit
AU - von Mutius, Erika
AU - Weber, Juliane
AU - Ahlfors, Helena
AU - Kallionpaa, Henna
AU - Laajala, Essi
AU - Lahesmaa, Riitta
AU - Lahdesmaki, Harri
AU - Moulder, Robert
AU - Nieminen, Janne
AU - Ruohtula, Terhi
AU - Harmsen, Hermie J. M.
AU - De Goffau, Marcus C.
PY - 2019/8
Y1 - 2019/8
N2 - Previous data about the role of viruses in the development of allergic immunoglobulin E (IgE) sensitization are contradictory. The aim of this study was to determine the possible associations between exposure to different viruses (rhinovirus, enterovirus, norovirus, and parechovirus) during the first year of life and IgE sensitization. Viruses were analyzed from stool samples collected monthly from infants participating in a prospective birth cohort study. From that study, 244 IgE sensitized case children and 244 nonsensitized control children were identified based on their allergen-specific IgE antibody levels at the age of 6, 18, and 36 months. Stool samples (n = 4576) from the case and control children were screened for the presence of rhinovirus, enterovirus, norovirus, and parechovirus RNA by reverse transcription quantitative polymerase chain reaction. The study showed that rhinovirus was the most prevalent virus detected, present in 921 (20%) samples. None of the viruses were associated with IgE sensitization in the full cohort but after stratifying by sex, the number of rhinovirus positive samples was inversely associated with IgE sensitization in boys (odds ratio [OR]: 0.81; 95% confidence interval [CI]: 0.69-0.94; P = 0.006). There was also a temporal relation between rhinoviruses and IgE sensitization, as rhinovirus exposure during the first 6 months of life was associated with a reduced risk of subsequent IgE sensitization in boys (OR: 0.76; 95% CI: 0.6-0.94; P = 0.016). In conclusion, early exposure to rhinoviruses was inversely associated with IgE sensitization but this protective association was restricted to boys.
AB - Previous data about the role of viruses in the development of allergic immunoglobulin E (IgE) sensitization are contradictory. The aim of this study was to determine the possible associations between exposure to different viruses (rhinovirus, enterovirus, norovirus, and parechovirus) during the first year of life and IgE sensitization. Viruses were analyzed from stool samples collected monthly from infants participating in a prospective birth cohort study. From that study, 244 IgE sensitized case children and 244 nonsensitized control children were identified based on their allergen-specific IgE antibody levels at the age of 6, 18, and 36 months. Stool samples (n = 4576) from the case and control children were screened for the presence of rhinovirus, enterovirus, norovirus, and parechovirus RNA by reverse transcription quantitative polymerase chain reaction. The study showed that rhinovirus was the most prevalent virus detected, present in 921 (20%) samples. None of the viruses were associated with IgE sensitization in the full cohort but after stratifying by sex, the number of rhinovirus positive samples was inversely associated with IgE sensitization in boys (odds ratio [OR]: 0.81; 95% confidence interval [CI]: 0.69-0.94; P = 0.006). There was also a temporal relation between rhinoviruses and IgE sensitization, as rhinovirus exposure during the first 6 months of life was associated with a reduced risk of subsequent IgE sensitization in boys (OR: 0.76; 95% CI: 0.6-0.94; P = 0.016). In conclusion, early exposure to rhinoviruses was inversely associated with IgE sensitization but this protective association was restricted to boys.
KW - allergy
KW - atopy
KW - sex
KW - stool
KW - virus
KW - ALLERGIC SENSITIZATION
KW - EARLY-CHILDHOOD
KW - ENTEROVIRUS INFECTIONS
KW - FECAL SAMPLES
KW - ASTHMA
KW - CHILDREN
KW - ATOPY
KW - POPULATION
KW - ASSOCIATION
KW - DISEASES
U2 - 10.1002/jmv.25455
DO - 10.1002/jmv.25455
M3 - Article
SN - 0146-6615
VL - 91
SP - 1470
EP - 1478
JO - Journal of Medical Virology
JF - Journal of Medical Virology
IS - 8
ER -