Abstract
Antidepressant discontinuation increases the risk of experiencing depressive symptoms. In a repeated single-subject design, we tested whether transitions in depression were preceded by increases in actigraphy-based critical-slowing-down-based early-warning signals (EWSs; variance, kurtosis, autocorrelation), circadian-rhythm-based indicators, and decreases in mean activity levels. Four months of data from 16 individuals with a transition in depression and nine without a transition in depression were analyzed using a moving-window method. As expected, more participants with a transition showed at least one EWS (50% true positives; 22.2% false positives). Increases in circadian rhythm variables (25.0% true positives vs. 44.4% false positives) and decreases in activity levels (37.5% true positives vs. 44.4% false positives) were more common in participants without a transition. None of the tested risk indicators could confidently predict upcoming transitions in depression, but some evidence was found that critical-slowing-down-based EWSs were more common in participants with a transition.
Original language | English |
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Pages (from-to) | 942-953 |
Number of pages | 12 |
Journal | Clinical Psychological Science |
Volume | 11 |
Issue number | 5 |
Early online date | 25-Mar-2023 |
DOIs | |
Publication status | Published - Sept-2023 |
Keywords
- actigraphy
- antidepressant discontinuation
- early warning signals
- personalized psychiatry
- repeated single-subject design