Risperidone-Induced Weight Gain in Referred Children with Autism Spectrum Disorders Is Associated with a Common Polymorphism in the 5-Hydroxytryptamine 2C Receptor Gene

Pieter J. Hoekstra; Pieter W. Troost; Bertine E. Lahuis; Hans Mulder; Erik J. Mulder; Barbara Franke; Jan K. Buitelaar; George M. Anderson; Lawrence Scahill; Ruud B. Minderaa

doi:10.1089/cap.2009.0071

Risperidone-Induced Weight Gain in Referred Children with Autism Spectrum Disorders Is Associated with a Common Polymorphism in the 5-Hydroxytryptamine 2C Receptor Gene

Pieter J. Hoekstra^*, Pieter W. Troost, Bertine E. Lahuis, Hans Mulder, Erik J. Mulder, Barbara Franke, Jan K. Buitelaar, George M. Anderson, Lawrence Scahill, Ruud B. Minderaa

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Weight gain is an important adverse effect of risperidone, but predictors of significant weight gain have yet to be identified in pediatric patients. Here, we investigated differences between age-and gender-normed body mass index-standardized z scores at baseline and after 8 weeks of open-label, flexible-dose risperidone treatment (mean dose: 1.70 mg/day) in 32 youths with pervasive developmental disorder (mean age 8.74, range 5-16 years) in relation to 759C/T 5-hydroxytryptamine 2C receptor (HTR2C) promoter and rs1414334 HTR2C intragenic C/G alleles, along with gender, age, and risperidone dose, using repeated measures analyses of variance. Carriers of the HTR2C promoter T allele gained an average of 0.043 +/- 0.017 body mass index-standardized z scores (1.84 +/- 1.51 kg) versus 0.64 +/- 0.35 z (3.23 +/- 1.47 kg) for non-T-allele carriers (p

Original language	English
Pages (from-to)	473-477
Number of pages	5
Journal	Journal of Child and Adolescent Psychopharmacology
Volume	20
Issue number	6
DOIs	https://doi.org/10.1089/cap.2009.0071
Publication status	Published - Dec-2010

Keywords

PERVASIVE DEVELOPMENTAL DISORDERS
BODY-WEIGHT
LONG-TERM
THE-759C/T POLYMORPHISM
C/T POLYMORPHISM
5-HT2C
ADOLESCENTS
CLOZAPINE
SCHIZOPHRENIA
OLANZAPINE

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Risperidone-Induced Weight Gain in Referred Children with Autism Spectrum Disorders Is Associated with a Common Polymorphism in the 5-Hydroxytryptamine 2C Receptor GeneFinal publisher's version, 147 KBLicence: Unspecified

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Hoekstra, P. J., Troost, P. W., Lahuis, B. E., Mulder, H., Mulder, E. J., Franke, B., Buitelaar, J. K., Anderson, G. M., Scahill, L., & Minderaa, R. B. (2010). Risperidone-Induced Weight Gain in Referred Children with Autism Spectrum Disorders Is Associated with a Common Polymorphism in the 5-Hydroxytryptamine 2C Receptor Gene. Journal of Child and Adolescent Psychopharmacology, 20(6), 473-477. https://doi.org/10.1089/cap.2009.0071

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title = "Risperidone-Induced Weight Gain in Referred Children with Autism Spectrum Disorders Is Associated with a Common Polymorphism in the 5-Hydroxytryptamine 2C Receptor Gene",

abstract = "Weight gain is an important adverse effect of risperidone, but predictors of significant weight gain have yet to be identified in pediatric patients. Here, we investigated differences between age-and gender-normed body mass index-standardized z scores at baseline and after 8 weeks of open-label, flexible-dose risperidone treatment (mean dose: 1.70 mg/day) in 32 youths with pervasive developmental disorder (mean age 8.74, range 5-16 years) in relation to 759C/T 5-hydroxytryptamine 2C receptor (HTR2C) promoter and rs1414334 HTR2C intragenic C/G alleles, along with gender, age, and risperidone dose, using repeated measures analyses of variance. Carriers of the HTR2C promoter T allele gained an average of 0.043 +/- 0.017 body mass index-standardized z scores (1.84 +/- 1.51 kg) versus 0.64 +/- 0.35 z (3.23 +/- 1.47 kg) for non-T-allele carriers (p",

keywords = "PERVASIVE DEVELOPMENTAL DISORDERS, BODY-WEIGHT, LONG-TERM, THE-759C/T POLYMORPHISM, C/T POLYMORPHISM, 5-HT2C, ADOLESCENTS, CLOZAPINE, SCHIZOPHRENIA, OLANZAPINE",

author = "Hoekstra, {Pieter J.} and Troost, {Pieter W.} and Lahuis, {Bertine E.} and Hans Mulder and Mulder, {Erik J.} and Barbara Franke and Buitelaar, {Jan K.} and Anderson, {George M.} and Lawrence Scahill and Minderaa, {Ruud B.}",

year = "2010",

month = dec,

doi = "10.1089/cap.2009.0071",

language = "English",

volume = "20",

pages = "473--477",

journal = "Journal of Child and Adolescent Psychopharmacology",

issn = "1044-5463",

publisher = "MARY ANN LIEBERT, INC",

number = "6",

}

Hoekstra, PJ, Troost, PW, Lahuis, BE, Mulder, H, Mulder, EJ, Franke, B, Buitelaar, JK, Anderson, GM, Scahill, L & Minderaa, RB 2010, 'Risperidone-Induced Weight Gain in Referred Children with Autism Spectrum Disorders Is Associated with a Common Polymorphism in the 5-Hydroxytryptamine 2C Receptor Gene', Journal of Child and Adolescent Psychopharmacology, vol. 20, no. 6, pp. 473-477. https://doi.org/10.1089/cap.2009.0071

Risperidone-Induced Weight Gain in Referred Children with Autism Spectrum Disorders Is Associated with a Common Polymorphism in the 5-Hydroxytryptamine 2C Receptor Gene. / Hoekstra, Pieter J.; Troost, Pieter W.; Lahuis, Bertine E. et al.
In: Journal of Child and Adolescent Psychopharmacology, Vol. 20, No. 6, 12.2010, p. 473-477.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Risperidone-Induced Weight Gain in Referred Children with Autism Spectrum Disorders Is Associated with a Common Polymorphism in the 5-Hydroxytryptamine 2C Receptor Gene

AU - Hoekstra, Pieter J.

AU - Troost, Pieter W.

AU - Lahuis, Bertine E.

AU - Mulder, Hans

AU - Mulder, Erik J.

AU - Franke, Barbara

AU - Buitelaar, Jan K.

AU - Anderson, George M.

AU - Scahill, Lawrence

AU - Minderaa, Ruud B.

PY - 2010/12

Y1 - 2010/12

N2 - Weight gain is an important adverse effect of risperidone, but predictors of significant weight gain have yet to be identified in pediatric patients. Here, we investigated differences between age-and gender-normed body mass index-standardized z scores at baseline and after 8 weeks of open-label, flexible-dose risperidone treatment (mean dose: 1.70 mg/day) in 32 youths with pervasive developmental disorder (mean age 8.74, range 5-16 years) in relation to 759C/T 5-hydroxytryptamine 2C receptor (HTR2C) promoter and rs1414334 HTR2C intragenic C/G alleles, along with gender, age, and risperidone dose, using repeated measures analyses of variance. Carriers of the HTR2C promoter T allele gained an average of 0.043 +/- 0.017 body mass index-standardized z scores (1.84 +/- 1.51 kg) versus 0.64 +/- 0.35 z (3.23 +/- 1.47 kg) for non-T-allele carriers (p

AB - Weight gain is an important adverse effect of risperidone, but predictors of significant weight gain have yet to be identified in pediatric patients. Here, we investigated differences between age-and gender-normed body mass index-standardized z scores at baseline and after 8 weeks of open-label, flexible-dose risperidone treatment (mean dose: 1.70 mg/day) in 32 youths with pervasive developmental disorder (mean age 8.74, range 5-16 years) in relation to 759C/T 5-hydroxytryptamine 2C receptor (HTR2C) promoter and rs1414334 HTR2C intragenic C/G alleles, along with gender, age, and risperidone dose, using repeated measures analyses of variance. Carriers of the HTR2C promoter T allele gained an average of 0.043 +/- 0.017 body mass index-standardized z scores (1.84 +/- 1.51 kg) versus 0.64 +/- 0.35 z (3.23 +/- 1.47 kg) for non-T-allele carriers (p

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KW - BODY-WEIGHT

KW - LONG-TERM

KW - THE-759C/T POLYMORPHISM

KW - C/T POLYMORPHISM

KW - 5-HT2C

KW - ADOLESCENTS

KW - CLOZAPINE

KW - SCHIZOPHRENIA

KW - OLANZAPINE

U2 - 10.1089/cap.2009.0071

DO - 10.1089/cap.2009.0071

M3 - Article

SN - 1044-5463

VL - 20

SP - 473

EP - 477

JO - Journal of Child and Adolescent Psychopharmacology

JF - Journal of Child and Adolescent Psychopharmacology

IS - 6

ER -

Risperidone-Induced Weight Gain in Referred Children with Autism Spectrum Disorders Is Associated with a Common Polymorphism in the 5-Hydroxytryptamine 2C Receptor Gene

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Keywords

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