Robust formation of biodegradable polymersomes by direct hydration

Xiaofeng Sui, Pekka Kujala, Geert-Jan Janssen, Edwin de Jong, Inge S. Zuhorn, Jan C. M. van Hest*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Abstract

Herein, we report a robust way for the formation of biodegradable poly(ethylene glycol)-block-poly(e-caprolactone) (PEG-b-PCL) polymersomes, via direct hydration of a highly concentrated block copolymer/oligo(ethylene glycol) solution. Polymersomes with variable membrane thickness were formed under relatively mild conditions in a short time, by changing the hydrophobic block length. Plunge freezing followed by cryo transmission electron microscopy (Cryo-TEM) was utilized to visualize the morphology of newly-formed polymersomes in their native condition. An MTT cytotoxicity study showed that the as-prepared polymersomes have good biocompatibility to hCMEC/D3 brain endothelial cells. As this method does not involve the use of small molecular organic solvent, sonication or freeze-thawing steps, it can offer the opportunity to form biodegradable polymersomes on-site. The work may facilitate the bench-to-bedside translation of biodegradable polymersomes as robust drug nanocarriers.

Original languageEnglish
Pages (from-to)691-696
Number of pages6
JournalPolymer Chemistry
Volume6
Issue number5
Early online date18-Nov-2014
DOIs
Publication statusPublished - 2015

Keywords

  • RING-OPENING POLYMERIZATION
  • BLOCK-COPOLYMERS
  • POLY(ETHYLENE GLYCOL)
  • DIBLOCK COPOLYMERS
  • BRAIN DELIVERY
  • VESICLES
  • DRUG
  • ASSEMBLIES
  • MICELLES
  • RELEASE

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