Role of the leptin signaling system in energy homeostasis

AB Steffens*, T Adage, K De Vries, R Adan, A Scheurink, G Van Dijk

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

A regulated factor that contributes to maintenance of energy homeostasis is body weight and especially the size of its fat mass. Leptin as well as insulin are synthesized and secreted in proportion to body fat and each form a unique link between energy availability and CNS mechanisms that subserve the regulation of energy homeostasis. Both insulin and leptin affect signaling systems in the hypothalamus that involve a number of neuropeptides that serve a role in the regulation of food intake and energy expenditure. This chapter pays attention to to the interactions of leptin and insulin with hypopthalamic neuronal circuitry that contains neuropeptide Y (NPY), agouti-related peptide (AgRP) and proopiomelanocortin (POMC), and how these interactions affect appropriate changes in food intake and energy expenditure.

Original languageEnglish
Title of host publicationPERSPECTIVE IN COMPARATIVE ENDOCRINOLOGY: UNITY AND DIVERSITY
EditorsH. Vaudry, H.J.Th. Goos, R.K. Rastogi, R. Pierantoni
Place of Publication40128 BOLOGNA
PublisherMEDIMOND PUBLISHING CO
Pages693-701
Number of pages9
ISBN (Print)88-323-1526-2
Publication statusPublished - 2001
Event14th International Congress of Comparative Endocrinology - , Italy
Duration: 26-May-200130-May-2001

Other

Other14th International Congress of Comparative Endocrinology
Country/TerritoryItaly
Period26/05/200130/05/2001

Keywords

  • NEUROPEPTIDE-Y
  • BODY-WEIGHT
  • FOOD-INTAKE
  • INSULIN
  • OBESITY
  • INJECTION
  • INFUSION
  • MOUSE
  • GENE

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