ROLES OF RADIATION DOSE AND CHEMOTHERAPY IN THE ETIOLOGY OF STOMACH CANCER AS A SECOND MALIGNANCY

Alexandra W. van den Belt-Dusebout; Berthe M. P. Aleman; Gijs Besseling; Marie L. de Bruin; Michael Hauptmann; Mars B. van 't Veer; Ronald de Wit; Jacques G. Ribot; Evert M. Noordijk; J. Martijn Kerst; Jourik A. Gietema; Flora E. van Leeuwen

doi:10.1016/j.ijrobp.2009.01.073

ROLES OF RADIATION DOSE AND CHEMOTHERAPY IN THE ETIOLOGY OF STOMACH CANCER AS A SECOND MALIGNANCY

Alexandra W. van den Belt-Dusebout
, Berthe M. P. Aleman
, Gijs Besseling
, Marie L. de Bruin
, Michael Hauptmann
, Mars B. van 't Veer
, Ronald de Wit
, Jacques G. Ribot
, Evert M. Noordijk
, J. Martijn Kerst
, Jourik A. Gietema
, Flora E. van Leeuwen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

93 Citations (Scopus)

Abstract

Purpose: To evaluate the roles of radiation dose, chemotherapy, and other factors in the etiology of stomach cancer in long-term survivors of testicular cancer or Hodgkin lymphoma.

Methods and Materials: We conducted a cohort study in 5,142 survivors of testicular cancer or Hodgkin lymphoma treated in the Netherlands between 1965 and 1995. In a nested case-control study, detailed information on treatment, smoking, gastrointestinal diseases, and family history was collected for 42 patients with stomach cancer and 126 matched controls. For each subject, the mean radiation dose to the stomach was estimated. Relative risks (RRs) of stomach cancer and the radiation-related excess relative risk (ERR) per gray were calculated by conditional logistic regression analysis.

Results: The risk of stomach cancer was 3.4-fold increased compared with the general population. The risk increased with increasing mean stomach dose (p for trend, = 13,000 mg) vs.

Conclusions: Stomach cancer risk is strongly radiation dose dependent. The role of chemotherapy, particularly of procarbazine and related agents, needs further study, because of the relatively small numbers of chemotherapy-treated subjects. (C) 2009 Elsevier Inc.

Original language	English
Pages (from-to)	1420-1429
Number of pages	10
Journal	International Journal of Radiation Oncology Biology Physics
Volume	75
Issue number	5
DOIs	https://doi.org/10.1016/j.ijrobp.2009.01.073
Publication status	Published - 1-Dec-2009

Keywords

Late treatment effects
Second primary cancer
Stomach cancer
Hodgkin lymphoma
Testicular cancer
LONG-TERM RISK
ATOMIC-BOMB SURVIVORS
GERM-CELL CANCER
HODGKINS-DISEASE
TESTICULAR CANCER
PEPTIC-ULCER
CARDIOVASCULAR-DISEASE
5-YEAR SURVIVORS
CHILDHOOD-CANCER
SOLID CANCER

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van den Belt-Dusebout, A. W., Aleman, B. M. P., Besseling, G., de Bruin, M. L., Hauptmann, M., van 't Veer, M. B., de Wit, R., Ribot, J. G., Noordijk, E. M., Kerst, J. M., Gietema, J. A., & van Leeuwen, F. E. (2009). ROLES OF RADIATION DOSE AND CHEMOTHERAPY IN THE ETIOLOGY OF STOMACH CANCER AS A SECOND MALIGNANCY. International Journal of Radiation Oncology Biology Physics, 75(5), 1420-1429. https://doi.org/10.1016/j.ijrobp.2009.01.073

@article{c0ed0dd6d62b46cfaa750b25154989dd,

title = "ROLES OF RADIATION DOSE AND CHEMOTHERAPY IN THE ETIOLOGY OF STOMACH CANCER AS A SECOND MALIGNANCY",

abstract = "Purpose: To evaluate the roles of radiation dose, chemotherapy, and other factors in the etiology of stomach cancer in long-term survivors of testicular cancer or Hodgkin lymphoma.Methods and Materials: We conducted a cohort study in 5,142 survivors of testicular cancer or Hodgkin lymphoma treated in the Netherlands between 1965 and 1995. In a nested case-control study, detailed information on treatment, smoking, gastrointestinal diseases, and family history was collected for 42 patients with stomach cancer and 126 matched controls. For each subject, the mean radiation dose to the stomach was estimated. Relative risks (RRs) of stomach cancer and the radiation-related excess relative risk (ERR) per gray were calculated by conditional logistic regression analysis.Results: The risk of stomach cancer was 3.4-fold increased compared with the general population. The risk increased with increasing mean stomach dose (p for trend, = 13,000 mg) vs.Conclusions: Stomach cancer risk is strongly radiation dose dependent. The role of chemotherapy, particularly of procarbazine and related agents, needs further study, because of the relatively small numbers of chemotherapy-treated subjects. (C) 2009 Elsevier Inc.",

keywords = "Late treatment effects, Second primary cancer, Stomach cancer, Hodgkin lymphoma, Testicular cancer, LONG-TERM RISK, ATOMIC-BOMB SURVIVORS, GERM-CELL CANCER, HODGKINS-DISEASE, TESTICULAR CANCER, PEPTIC-ULCER, CARDIOVASCULAR-DISEASE, 5-YEAR SURVIVORS, CHILDHOOD-CANCER, SOLID CANCER",

author = "\{van den Belt-Dusebout\}, \{Alexandra W.\} and Aleman, \{Berthe M. P.\} and Gijs Besseling and \{de Bruin\}, \{Marie L.\} and Michael Hauptmann and \{van 't Veer\}, \{Mars B.\} and \{de Wit\}, Ronald and Ribot, \{Jacques G.\} and Noordijk, \{Evert M.\} and Kerst, \{J. Martijn\} and Gietema, \{Jourik A.\} and \{van Leeuwen\}, \{Flora E.\}",

year = "2009",

month = dec,

day = "1",

doi = "10.1016/j.ijrobp.2009.01.073",

language = "English",

volume = "75",

pages = "1420--1429",

journal = "International Journal of Radiation Oncology Biology Physics",

issn = "0360-3016",

publisher = "ELSEVIER SCIENCE INC",

number = "5",

}

van den Belt-Dusebout, AW, Aleman, BMP, Besseling, G, de Bruin, ML, Hauptmann, M, van 't Veer, MB, de Wit, R, Ribot, JG, Noordijk, EM, Kerst, JM, Gietema, JA & van Leeuwen, FE 2009, 'ROLES OF RADIATION DOSE AND CHEMOTHERAPY IN THE ETIOLOGY OF STOMACH CANCER AS A SECOND MALIGNANCY', International Journal of Radiation Oncology Biology Physics, vol. 75, no. 5, pp. 1420-1429. https://doi.org/10.1016/j.ijrobp.2009.01.073

ROLES OF RADIATION DOSE AND CHEMOTHERAPY IN THE ETIOLOGY OF STOMACH CANCER AS A SECOND MALIGNANCY. / van den Belt-Dusebout, Alexandra W.; Aleman, Berthe M. P.; Besseling, Gijs et al.
In: International Journal of Radiation Oncology Biology Physics, Vol. 75, No. 5, 01.12.2009, p. 1420-1429.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - ROLES OF RADIATION DOSE AND CHEMOTHERAPY IN THE ETIOLOGY OF STOMACH CANCER AS A SECOND MALIGNANCY

AU - van den Belt-Dusebout, Alexandra W.

AU - Aleman, Berthe M. P.

AU - Besseling, Gijs

AU - de Bruin, Marie L.

AU - Hauptmann, Michael

AU - van 't Veer, Mars B.

AU - de Wit, Ronald

AU - Ribot, Jacques G.

AU - Noordijk, Evert M.

AU - Kerst, J. Martijn

AU - Gietema, Jourik A.

AU - van Leeuwen, Flora E.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Purpose: To evaluate the roles of radiation dose, chemotherapy, and other factors in the etiology of stomach cancer in long-term survivors of testicular cancer or Hodgkin lymphoma.Methods and Materials: We conducted a cohort study in 5,142 survivors of testicular cancer or Hodgkin lymphoma treated in the Netherlands between 1965 and 1995. In a nested case-control study, detailed information on treatment, smoking, gastrointestinal diseases, and family history was collected for 42 patients with stomach cancer and 126 matched controls. For each subject, the mean radiation dose to the stomach was estimated. Relative risks (RRs) of stomach cancer and the radiation-related excess relative risk (ERR) per gray were calculated by conditional logistic regression analysis.Results: The risk of stomach cancer was 3.4-fold increased compared with the general population. The risk increased with increasing mean stomach dose (p for trend, = 13,000 mg) vs.Conclusions: Stomach cancer risk is strongly radiation dose dependent. The role of chemotherapy, particularly of procarbazine and related agents, needs further study, because of the relatively small numbers of chemotherapy-treated subjects. (C) 2009 Elsevier Inc.

AB - Purpose: To evaluate the roles of radiation dose, chemotherapy, and other factors in the etiology of stomach cancer in long-term survivors of testicular cancer or Hodgkin lymphoma.Methods and Materials: We conducted a cohort study in 5,142 survivors of testicular cancer or Hodgkin lymphoma treated in the Netherlands between 1965 and 1995. In a nested case-control study, detailed information on treatment, smoking, gastrointestinal diseases, and family history was collected for 42 patients with stomach cancer and 126 matched controls. For each subject, the mean radiation dose to the stomach was estimated. Relative risks (RRs) of stomach cancer and the radiation-related excess relative risk (ERR) per gray were calculated by conditional logistic regression analysis.Results: The risk of stomach cancer was 3.4-fold increased compared with the general population. The risk increased with increasing mean stomach dose (p for trend, = 13,000 mg) vs.Conclusions: Stomach cancer risk is strongly radiation dose dependent. The role of chemotherapy, particularly of procarbazine and related agents, needs further study, because of the relatively small numbers of chemotherapy-treated subjects. (C) 2009 Elsevier Inc.

KW - Late treatment effects

KW - Second primary cancer

KW - Stomach cancer

KW - Hodgkin lymphoma

KW - Testicular cancer

KW - LONG-TERM RISK

KW - ATOMIC-BOMB SURVIVORS

KW - GERM-CELL CANCER

KW - HODGKINS-DISEASE

KW - TESTICULAR CANCER

KW - PEPTIC-ULCER

KW - CARDIOVASCULAR-DISEASE

KW - 5-YEAR SURVIVORS

KW - CHILDHOOD-CANCER

KW - SOLID CANCER

U2 - 10.1016/j.ijrobp.2009.01.073

DO - 10.1016/j.ijrobp.2009.01.073

M3 - Article

SN - 0360-3016

VL - 75

SP - 1420

EP - 1429

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

IS - 5

ER -

ROLES OF RADIATION DOSE AND CHEMOTHERAPY IN THE ETIOLOGY OF STOMACH CANCER AS A SECOND MALIGNANCY

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Keywords

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