Routine detection of serum anti-desmocollin autoantibodies is only useful in patients with atypical pemphigus

Swantje Mindorf, Inga M Dettmann, Stine Krüger, Tarek Fuhrmann, Kristin Rentzsch, Ingolf Karl, Christian Probst, Lars Komorowski, Kai Fechner, Nina van Beek, Susanne Lemcke, Miklós Sárdy, Christine Bangert, Sandrine Benoit, Takashi Hashimoto, Detlef Zillikens, Hendri H Pas, Marcel F Jonkman, Winfried Stöcker, Enno SchmidtInternational Autoimmune Bullous Diseases Study Group

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

24 Citations (Scopus)

Abstract

Autoantibodies against the 3 desmocollin (Dsc; Dsc1-Dsc3) isoforms have been described in different pemphigus variants. Here, we developed state-of-the-art detection systems for serum anti-Dsc1, Dsc2 and Dsc1 IgG and IgA. These assays were applied in 5 different cohorts including pemphigus vulgaris (PV) patients with compatible direct immunofluorescence (IF) microscopy but no reactivity against desmogleins 1 and 3 (n = 24) and sera from patients with autoimmune blistering diseases with positive direct IF microscopy taken at the time of diagnosis (n = 749). We found that detection of anti-Dsc serum reactivity is not helpful in the routine diagnosis of PV, pemphigus foliaceus and paraneoplastic pemphigus but may be valuable in pemphigus vegetans.
Original languageEnglish
Pages (from-to)1267-1270
Number of pages4
JournalExperimental dermatology
Volume26
Issue number12
Early online date29-Oct-2017
DOIs
Publication statusPublished - Dec-2017

Keywords

  • Journal Article
  • DESMOCOLLINS
  • foliaceus
  • vulgaris vegetans
  • atypical
  • autoantibody
  • diagnosis

Cite this