S-100B as an extra selection tool for FDG PET/CT scanning in follow-up of AJCC stage III melanoma patients

Eric A. Deckers, Kevin P. Wevers, Anneke C. Muller Kobold, Samantha Damude, Otis M. Vrielink, Robert J. van Ginkel, Lukas B. Been, Barbara L. van Leeuwen, Harald J. Hoekstra, Schelto Kruijff*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Background and Objectives This current study assessed the value of S-100B measurement to guide fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) scanning for detecting recurrent disease in stage III melanoma patients. Methods This study included 100 stage III melanoma patients in follow-up after curative lymph node dissection. Follow-up visits included physical examination and S-100B monitoring. FDG PET/CT scanning was indicated by clinical symptoms and/or elevated S-100B. Results Of 100 patients, 13 (13%) had elevated S-100B without clinical symptoms, of whom 7 (54%) showed disease evidence upon FDG PET/CT scanning. Twenty-six patients (26%) had clinical symptoms with normal S-100B and FDG PET/CT revealed metastasis in 20 (77%). Three patients had clinical symptoms and elevated S-100B, and FDG PET/CT revealed metastasis in all three (100%). Overall, FDG PET/CT scanning revealed metastasis in 30 of the 42 patients (71.4%). For seven recurrences, elevated S-100B prompted early detection of asymptomatic disease; 10% of all asymptomatic patients in follow-up, 23% of all patients with recurrent disease. Conclusion S-100B cannot exclude recurrent disease during follow-up of stage III melanoma. However, adding S-100B measurement to standard clinical assessment can guide FDG PET/CT scanning for detecting recurrent melanoma.

Original languageEnglish
Pages (from-to)1031-1037
Number of pages7
JournalJournal of Surgical Oncology
Issue number6
Publication statusPublished - 5-Aug-2019


  • biomarker
  • CT
  • follow-up
  • melanoma
  • recurrence
  • S-100B

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