Safety of treatments for primary Sjogren's syndrome

Jolien F. van Nimwegen, R. V. Moerman, Nicole Sillevis Smitt, Elisabeth Brouwer, Hendrika Bootsma, Arjan Vissink*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

8 Citations (Scopus)

Abstract

Introduction: Primary Sjogren's syndrome (pSS) is a disabling auto-immune disease, affecting exocrine glands and several organs.Areas covered: In this review we analyze the safety of therapies used in pSS. Symptomatic treatment is widely applied due to the good supportive effect and good safety profile. Systemic stimulation of tears and saliva can be successful in pSS. However, cumbersome adverse events can influence the tolerability of this therapy. Evidence for the effectiveness of synthetic DMARDs therapies in pSS is limited, while there is a risk of adverse events. Several studies on biologic DMARD treatment of pSS patients have shown promising efficacy and safety results.Expert opinion: The safety of symptomatic treatment of pSS is very good. However, systemic therapy is necessary to achieve long-term relieve and prevention of organ-damage. Synthetic DMARDs have not shown much efficacy in earlier studies, and their benefits do not weigh up to the possible harms, while biologic DMARDs show promising results regarding efficacy and cause mostly mild adverse events. Many questions remain unanswered regarding safety of DMARDs in pSS. There is a need for well designed studies, in which safety should be evaluated in a uniform manner to be able to compare the results between studies.

Original languageEnglish
Pages (from-to)513-524
Number of pages12
JournalExpert Opinion on Drug Safety
Volume15
Issue number4
DOIs
Publication statusPublished - 2-Apr-2016

Keywords

  • Primary Sjogren's syndrome
  • drug safety
  • topical treatment
  • synthetic DMARDs
  • biologic DMARDs
  • SYSTEMIC-LUPUS-ERYTHEMATOSUS
  • PLACEBO-CONTROLLED TRIAL
  • PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY
  • AUTOLOGOUS SERUM APPLICATION
  • DYSFUNCTIONAL TEAR SYNDROME
  • CONNECTIVE-TISSUE DISEASES
  • RANDOMIZED-CLINICAL-TRIAL
  • INTERSTITIAL LUNG-DISEASE
  • GOBLET CELL-DENSITY
  • DRY EYE SYMPTOMS

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