Salicylic acid and picolinic acid derivatives as inhibitors of energy coupling factor (ecf) transporters for the treatment of bacterial infections

Eleonora Diamanti; Mostafa Hamed Exapichei; Loulia-Antonia Exapicheidou; Jennifer Hermann; Rolf Müller; Anna Hirsch; Lotteke Ziel-Swier; Dirk Slotboom; Paddy Gibson; Jan-Willem Veening

Salicylic acid and picolinic acid derivatives as inhibitors of energy coupling factor (ecf) transporters for the treatment of bacterial infections

Eleonora Diamanti (Inventor)
, Mostafa Hamed Exapichei (Inventor)
, Loulia-Antonia Exapicheidou (Inventor)
, Jennifer Hermann (Inventor)
, Rolf Müller (Inventor)
, Anna Hirsch (Inventor)
, Lotteke Ziel-Swier (Inventor)
, Dirk Slotboom (Inventor)
, Paddy Gibson (Inventor)
, Jan-Willem Veening (Inventor)

Research output: Patent

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Abstract

The present invention relates to novel inhibitors of the Energy Coupling Factor (ECF) Transporters. These compounds of general formula (I) are useful in the treatment of bacterial infections, especially caused by Streptococcus pneumoniae, Enterococcus faecium, Enterococcus faecalis.

Original language	English
Patent number	WO2025104079
Priority date	17/11/2023
Filing date	13/11/2024
Publication status	Published - 22-May-2025

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title = "Salicylic acid and picolinic acid derivatives as inhibitors of energy coupling factor (ecf) transporters for the treatment of bacterial infections",

abstract = "The present invention relates to novel inhibitors of the Energy Coupling Factor (ECF) Transporters. These compounds of general formula (I) are useful in the treatment of bacterial infections, especially caused by Streptococcus pneumoniae, Enterococcus faecium, Enterococcus faecalis.",

author = "Eleonora Diamanti and \{Hamed Exapichei\}, Mostafa and Loulia-Antonia Exapicheidou and Jennifer Hermann and Rolf M{\"u}ller and Anna Hirsch and Lotteke Ziel-Swier and Dirk Slotboom and Paddy Gibson and Jan-Willem Veening",

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month = may,

day = "22",

language = "English",

type = "Patent",

note = "WO2025104079",

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T1 - Salicylic acid and picolinic acid derivatives as inhibitors of energy coupling factor (ecf) transporters for the treatment of bacterial infections

AU - Diamanti, Eleonora

AU - Hamed Exapichei, Mostafa

AU - Exapicheidou, Loulia-Antonia

AU - Hermann, Jennifer

AU - Müller, Rolf

AU - Hirsch, Anna

AU - Ziel-Swier, Lotteke

AU - Slotboom, Dirk

AU - Gibson, Paddy

AU - Veening, Jan-Willem

PY - 2025/5/22

Y1 - 2025/5/22

N2 - The present invention relates to novel inhibitors of the Energy Coupling Factor (ECF) Transporters. These compounds of general formula (I) are useful in the treatment of bacterial infections, especially caused by Streptococcus pneumoniae, Enterococcus faecium, Enterococcus faecalis.

AB - The present invention relates to novel inhibitors of the Energy Coupling Factor (ECF) Transporters. These compounds of general formula (I) are useful in the treatment of bacterial infections, especially caused by Streptococcus pneumoniae, Enterococcus faecium, Enterococcus faecalis.

M3 - Patent

M1 - WO2025104079

Y2 - 2024/11/13

ER -

Salicylic acid and picolinic acid derivatives as inhibitors of energy coupling factor (ecf) transporters for the treatment of bacterial infections

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