Salivary gland organoids to study radiation-induced microenvironmental changes: a versatile translational tool

    Research output: ThesisThesis fully internal (DIV)

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    The work described in this thesis focused on two main points. Firstly, we aimed to unravel the effect of radiation-induced microenvironmental changes on the regenerative potential of SGSCs and investigate the possible modulation or intervention of microenvironmental factors to improve SGSC function by using salivary gland organoids as a model. Secondly, we utilized human salivary gland biopsy-derived organoids to explore the SARS-CoV-2 infection process.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    • Coppes, Rob, Supervisor
    • Vissink, Arjan, Supervisor
    • Barazzuol, Lara, Co-supervisor
    • Pringle, Sarah, Co-supervisor
    Award date26-Sept-2022
    Place of Publication[Groningen]
    Publication statusPublished - 2022

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