Salivary gland organoids to study radiation-induced microenvironmental changes: a versatile translational tool

Yi Wu

doi:10.33612/diss.240663975

Salivary gland organoids to study radiation-induced microenvironmental changes: a versatile translational tool

Yi Wu

Research output: Thesis › Thesis fully internal (DIV)

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Abstract

The work described in this thesis focused on two main points. Firstly, we aimed to unravel the effect of radiation-induced microenvironmental changes on the regenerative potential of SGSCs and investigate the possible modulation or intervention of microenvironmental factors to improve SGSC function by using salivary gland organoids as a model. Secondly, we utilized human salivary gland biopsy-derived organoids to explore the SARS-CoV-2 infection process.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Groningen
Supervisors/Advisors	Coppes, Rob, Supervisor Vissink, Arjan, Supervisor Barazzuol, Lara, Co-supervisor Pringle, Sarah, Co-supervisor
Award date	26-Sept-2022
Place of Publication	[Groningen]
Publisher	University of Groningen
DOIs	https://doi.org/10.33612/diss.240663975
Publication status	Published - 2022

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10.33612/diss.240663975

Title and contentsFinal publisher's version, 2.71 MB
Chapter 1Final publisher's version, 890 KB
Chapter 3Final publisher's version, 2.15 MB
Chapter 6Final publisher's version, 964 KB
AppendicesFinal publisher's version, 670 KB
PropositionsFinal publisher's version, 44.6 KB

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Cite this

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title = "Salivary gland organoids to study radiation-induced microenvironmental changes: a versatile translational tool",

abstract = "The work described in this thesis focused on two main points. Firstly, we aimed to unravel the effect of radiation-induced microenvironmental changes on the regenerative potential of SGSCs and investigate the possible modulation or intervention of microenvironmental factors to improve SGSC function by using salivary gland organoids as a model. Secondly, we utilized human salivary gland biopsy-derived organoids to explore the SARS-CoV-2 infection process.",

author = "Yi Wu",

year = "2022",

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language = "English",

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AU - Wu, Yi

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AB - The work described in this thesis focused on two main points. Firstly, we aimed to unravel the effect of radiation-induced microenvironmental changes on the regenerative potential of SGSCs and investigate the possible modulation or intervention of microenvironmental factors to improve SGSC function by using salivary gland organoids as a model. Secondly, we utilized human salivary gland biopsy-derived organoids to explore the SARS-CoV-2 infection process.

U2 - 10.33612/diss.240663975

DO - 10.33612/diss.240663975

M3 - Thesis fully internal (DIV)

PB - University of Groningen

CY - [Groningen]

ER -